Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL226938 | 0.82 | CHEK1 (0.42) | CA2 | |
| SCHEMBL23458116 | 0.79 | CA2 (0.42) | CA2 | |
| SCHEMBL29862159 | 0.79 | CA2 (0.42) | CA2 | |
| SCHEMBL4014825 | 0.75 | CRHR1 (0.37) | — | |
| SCHEMBL297736 | 0.74 | AR (0.33) | — | |
| SCHEMBL297647 | 0.72 | CRHR1 (0.36) | — | |
| SCHEMBL29862152 | 0.72 | SIGMAR1 (0.55) | — | |
| SCHEMBL18387836 | 0.72 | SIGMAR1 (0.55) | — | |
| SCHEMBL9830323 | 0.71 | ELANE (0.32) | — | |
| SCHEMBL8312100 | 0.71 | GABRA1 (0.40) | CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1061652-C | Endotheliomycine receptor antagonist | MERCK PATENT GMBH (DE) | 2001-02-07 | — | — | CN | disclosed |
| EP-0733626-B1 | N-(Benzofuranazyl)-arylsulphonamides and their analogues useful as endothelin-receptor-antagonists | MERCK PATENT GMBH (DE) | 1999-01-13 | — | — | EP | disclosed |
| US-5726194-A | Endothelin receptor antagonists | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1998-03-10 | — | — | US | disclosed |
| CN-1141919-A | Endotheliomycine receptor antagonist | MOOK PATENT AG (DE) | 1997-02-05 | — | — | CN | disclosed |
| EP-0733626-A1 | N-(Benzofuranazyl)-arylsulphonamides and their analogues useful as endothelin-receptor-antagonists | MERCK PATENT GmbH (DE) | 1996-09-25 | — | — | EP | disclosed |