Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.39 |
| ▸ | MEN1 | O00255 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8313620 | 0.93 | P2RX7 (0.34) | ALDH1A1HPGDGLAKMT2AMEN1 | |
| SCHEMBL8318118 | 0.89 | ALDH1A1 (0.45) | ALDH1A1HPGDGLAKMT2AMEN1 | |
| SCHEMBL8312553 | 0.86 | ALDH1A1 (0.40) | ALDH1A1HPGDGLAKMT2AMEN1 | |
| SCHEMBL8313835 | 0.84 | KMT2A (0.42) | ALDH1A1HPGDGLAKMT2AMEN1 | |
| SCHEMBL8316536 | 0.84 | MEN1 (0.32) | ALDH1A1KMT2AMEN1SMN1; SMN2MAPK1 | |
| SCHEMBL8317246 | 0.82 | KMT2A (0.45) | ALDH1A1HPGDGLAKMT2AMEN1 | |
| SCHEMBL9536573 | 0.81 | MEN1 (0.43) | HPGDKMT2AMEN1TSHRSMN1; SMN2 | |
| SCHEMBL8877101 | 0.81 | ALDH1A1 (0.42) | ALDH1A1HPGDGLAKMT2AMEN1 | |
| SCHEMBL8317256 | 0.81 | ALDH1A1 (0.39) | ALDH1A1HPGDGLAKMT2AMEN1 | |
| SCHEMBL8314523 | 0.81 | KMT2A (0.38) | ALDH1A1HPGDKMT2AMEN1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0501129-B1 | Substituted bicyclic 3-arylpyrrolidin-2,4-dion derivatives | BAYER AG (DE) | 1999-07-14 | — | — | EP | disclosed |
| EP-0501129-A1 | Substituted bicyclic 3-arylpyrrolidin-2,4-dion derivatives | BAYER AG (DE) | 1992-09-02 | — | — | EP | disclosed |