Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | CCR1 | P32246 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.32 |
| ▸ | POLB | P06746 | 2/20 | 0.31 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.31 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.31 |
| ▸ | TAS1R2 | Q8TE23 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 2/20 | 0.30 |
| ▸ | ACE | P12821 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8314253 | 0.89 | KMT2A (0.36) | KMT2AMEN1CCR1POLBALDH1A1 | |
| SCHEMBL8315795 | 0.87 | CCR1 (0.37) | KMT2AMEN1CCR1POLBALDH1A1 | |
| SCHEMBL8313857 | 0.85 | KMT2A (0.35) | KMT2AMEN1CCR1POLBALDH1A1 | |
| SCHEMBL8312908 | 0.83 | KMT2A (0.45) | KMT2AMEN1POLBALDH1A1SMN1; SMN2 | |
| SCHEMBL8313620 | 0.83 | P2RX7 (0.34) | KMT2AMEN1MAPK1POLBALDH1A1 | |
| SCHEMBL8874920 | 0.83 | KMT2A (0.39) | KMT2AMEN1EPHX2MAPK1POLB | |
| SCHEMBL8315905 | 0.81 | ALDH1A1 (0.40) | KMT2AMEN1MAPK1ALDH1A1HPGD | |
| SCHEMBL9220150 | 0.80 | KMT2A (0.44) | KMT2AMEN1POLBALDH1A1SMN1; SMN2 | |
| SCHEMBL8314804 | 0.79 | SIGMAR1 (0.43) | KMT2AMAPK1POLBALDH1A1SMN1; SMN2 | |
| SCHEMBL9536573 | 0.79 | MEN1 (0.43) | KMT2AMEN1EPHX2MAPK1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0501129-B1 | Substituted bicyclic 3-arylpyrrolidin-2,4-dion derivatives | BAYER AG (DE) | 1999-07-14 | — | — | EP | disclosed |
| EP-0501129-A1 | Substituted bicyclic 3-arylpyrrolidin-2,4-dion derivatives | BAYER AG (DE) | 1992-09-02 | — | — | EP | disclosed |