Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.33 |
| ▸ | ATM | Q13315 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.33 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8318118 | 0.93 | ALDH1A1 (0.45) | ALDH1A1GLAHPGDKMT2AMEN1 | |
| SCHEMBL8318010 | 0.88 | KMT2A (0.47) | ALDH1A1GLAHPGDKMT2AMEN1 | |
| SCHEMBL8313620 | 0.88 | P2RX7 (0.34) | ALDH1A1GLAHPGDKMT2AMEN1 | |
| SCHEMBL8312985 | 0.86 | ALDH1A1 (0.34) | ALDH1A1GLAHPGDKMT2AMEN1 | |
| SCHEMBL8314253 | 0.83 | KMT2A (0.36) | ALDH1A1KMT2AMEN1SMN1; SMN2MAPT | |
| SCHEMBL8316864 | 0.82 | ALDH1A1 (0.38) | ALDH1A1KMT2AMEN1SMN1; SMN2MAPT | |
| SCHEMBL8317246 | 0.82 | KMT2A (0.45) | ALDH1A1GLAHPGDKMT2AMEN1 | |
| SCHEMBL8315905 | 0.81 | ALDH1A1 (0.40) | ALDH1A1GLAHPGDKMT2AMEN1 | |
| SCHEMBL8317474 | 0.81 | KMT2A (0.35) | ALDH1A1HPGDKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL8875077 | 0.81 | KMT2A (0.42) | ALDH1A1GLAHPGDKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0501129-B1 | Substituted bicyclic 3-arylpyrrolidin-2,4-dion derivatives | BAYER AG (DE) | 1999-07-14 | — | — | EP | disclosed |
| EP-0501129-A1 | Substituted bicyclic 3-arylpyrrolidin-2,4-dion derivatives | BAYER AG (DE) | 1992-09-02 | — | — | EP | disclosed |