Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 2/20 | 0.52 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.52 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.52 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.52 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.52 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.52 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.52 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.52 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.52 |
| ▸ | EDNRA | P25101 | 1/20 | 0.48 |
| ▸ | CDC7 | O00311 | 1/20 | 0.47 |
| ▸ | EEF2K | O00418 | 1/20 | 0.47 |
| ▸ | PLK4 | O00444 | 1/20 | 0.47 |
| ▸ | AURKA | O14965 | 1/20 | 0.47 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.47 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.47 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.47 |
| ▸ | PIM1 | P11309 | 1/20 | 0.47 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6764847 | 0.85 | PIK3CD (0.68) | PTPN1HSPD1PTPN2PTPN5HSPE1 | |
| SCHEMBL6760774 | 0.82 | CDC7 (0.64) | PTPN1HSPD1PTPN2PTPN5HSPE1 | |
| SCHEMBL8541050 | 0.81 | PIK3CD (0.57) | PTPN1HSPD1PTPN2PTPN5HSPE1 | |
| SCHEMBL8315471 | 0.81 | ALDH1A1 (0.56) | PTPN1HSPD1PTPN2PTPN5HSPE1 | |
| SCHEMBL19966690 | 0.81 | PTPN11 (0.60) | PTPN1LMNASMN1; SMN2HTTALDH1A1 | |
| SCHEMBL6762244 | 0.78 | TXNRD1 (0.59) | PTPN1HSPD1PTPN2PTPN5HSPE1 | |
| SCHEMBL8317574 | 0.77 | PIK3CD (0.54) | PTPN1HSPD1PTPN2PTPN5HSPE1 | |
| SCHEMBL6394861 | 0.76 | EDNRA (0.66) | PTPN5EDNRATSHRLMNASMN1; SMN2 | |
| SCHEMBL8313917 | 0.73 | POLB (0.58) | PTPN1HSPD1PTPN2PTPN5HSPE1 | |
| SCHEMBL18553781 | 0.73 | HTR6 (0.60) | PTPN1HSPD1PTPN2PTPN5HSPE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0733626-B1 | N-(Benzofuranazyl)-arylsulphonamides and their analogues useful as endothelin-receptor-antagonists | MERCK PATENT GMBH (DE) | 1999-01-13 | — | — | EP | disclosed |
| US-5726194-A | Endothelin receptor antagonists | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1998-03-10 | — | — | US | disclosed |
| EP-0733626-A1 | N-(Benzofuranazyl)-arylsulphonamides and their analogues useful as endothelin-receptor-antagonists | MERCK PATENT GmbH (DE) | 1996-09-25 | — | — | EP | disclosed |