Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 1/20 | 0.57 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.57 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.57 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 3/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | PKM | P14618 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | PTPN1 | P18031 | 4/20 | 0.54 |
| ▸ | PTPN2 | P17706 | 3/20 | 0.54 |
| ▸ | PTPN5 | P54829 | 3/20 | 0.54 |
| ▸ | HSPD1 | P10809 | 2/20 | 0.54 |
| ▸ | HSPE1 | P61604 | 2/20 | 0.54 |
| ▸ | EDNRA | P25101 | 1/20 | 0.53 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8317574 | 0.92 | PIK3CD (0.54) | PIK3CDPIK3CAPIK3CBPIK3CGLMNA | |
| SCHEMBL6760774 | 0.85 | CDC7 (0.64) | PIK3CDPIK3CAPIK3CBPIK3CGLMNA | |
| SCHEMBL6764847 | 0.85 | PIK3CD (0.68) | PIK3CDPIK3CAPIK3CBPIK3CGLMNA | |
| SCHEMBL8313917 | 0.84 | POLB (0.58) | PIK3CDPIK3CAPIK3CBPIK3CGLMNA | |
| SCHEMBL6762244 | 0.81 | TXNRD1 (0.59) | PIK3CDPIK3CAPIK3CBPIK3CGMEN1 | |
| SCHEMBL8315991 | 0.81 | PTPN1 (0.52) | PIK3CDPIK3CAPIK3CBPIK3CGLMNA | |
| SCHEMBL8315471 | 0.81 | ALDH1A1 (0.56) | PIK3CDPIK3CAPIK3CBPIK3CGLMNA | |
| SCHEMBL6320114 | 0.80 | EDNRA (0.56) | LMNAKMT2AMAPTTSHRALDH1A1 | |
| SCHEMBL8313260 | 0.80 | L3MBTL1 (0.64) | LMNAMEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL9613356 | 0.76 | PTPN1 (0.60) | LMNASMN1; SMN2MEN1KMT2APKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5726194-A | Endothelin receptor antagonists | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1998-03-10 | — | — | US | disclosed |