Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VCAM1 | P19320 | 13/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.46 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4298089 | 0.79 | VCAM1 (0.56) | VCAM1TDP1TSHRMAPK1NPBWR1 | |
| SCHEMBL5992360 | 0.78 | VCAM1 (0.60) | VCAM1TDP1TSHRMAPK1 | |
| SCHEMBL358730 | 0.78 | MAPK1 (0.69) | VCAM1TDP1TSHRMAPK1 | |
| SCHEMBL29394047 | 0.78 | MAPK1 (0.69) | VCAM1TDP1TSHRMAPK1 | |
| SCHEMBL11496559 | 0.78 | TSHR (0.41) | TDP1TSHRMAPK1HSD17B10 | |
| Dinitrochlorobenzene SCHEMBL39251 | 0.77 | HSD17B10 (0.69) | VCAM1TDP1TSHRMAPK1HSD17B10 | |
| SCHEMBL2461199 | 0.77 | VCAM1 (0.58) | VCAM1TDP1TSHRMAPK1 | |
| Dinitrochlorobenzene SCHEMBL20472381 | 0.77 | HSD17B10 (0.69) | VCAM1TDP1TSHRMAPK1HSD17B10 | |
| Dinitrochlorobenzene SCHEMBL29349476 | 0.77 | HSD17B10 (0.69) | VCAM1TDP1TSHRMAPK1HSD17B10 | |
| Ammonia Solution, Strong SCHEMBL28805237 | 0.77 | MAPK1 (0.67) | VCAM1TDP1TSHRMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0888351-A1 | PYRIMIDO 5,4-D]PYRIMIDINES, MEDICAMENTS CONTAINING THESE COMPOUNDS, THEIR USE AND PROCESS FOR THEIR PRODUCTION | Dr. Karl Thomae GmbH (DE) | 1999-01-07 | — | — | EP | claimed |
| WO-1997032880-A1 | PYRIMIDO[5,4-D]PYRIMIDINES, MEDICAMENTS CONTAINING THESE COMPOUNDS, THEIR USE AND PROCESS FOR THEIR PRODUCTION | DR. KARL THOMAE GMBH (DE) | 1997-09-12 | — | — | WO | claimed |
| EP-0888351-A1 | PYRIMIDO 5,4-D]PYRIMIDINES, MEDICAMENTS CONTAINING THESE COMPOUNDS, THEIR USE AND PROCESS FOR THEIR PRODUCTION | Dr. Karl Thomae GmbH (DE) | 1999-01-07 | — | — | EP | disclosed |
| US-5821240-A | ENZYME INHIBITORS, SIGNAL INHIBITORS FOR ANTIINFLAMMATORY AGENTS, ANTICARCINOGENIC AGENTS, ANTITUMOR AGENTS AND HORMONE INHIBITORS | DR. KARL THOMAE GMBH (DE) | 1998-10-13 | — | — | US | disclosed |
| WO-1997032880-A1 | PYRIMIDO[5,4-D]PYRIMIDINES, MEDICAMENTS CONTAINING THESE COMPOUNDS, THEIR USE AND PROCESS FOR THEIR PRODUCTION | DR. KARL THOMAE GMBH (DE) | 1997-09-12 | — | — | WO | disclosed |