Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | NFKBIA | P25963 | 1/20 | 0.49 |
| ▸ | RELA | Q04206 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | IDH1 | O75874 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | PDE2A | O00408 | 1/20 | 0.46 |
| ▸ | PDE5A | O76074 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8311524 | 0.84 | MEN1 (0.56) | SMN1; SMN2L3MBTL1TDP1PKMNFKBIA | |
| SCHEMBL8310859 | 0.83 | HSPD1 (0.59) | SMN1; SMN2TDP1MAPTPOLBMEN1 | |
| SCHEMBL8315915 | 0.81 | CDK2 (0.48) | SMN1; SMN2MAPTGAAMEN1KMT2A | |
| SCHEMBL8316197 | 0.80 | SMN1; SMN2 (0.50) | SMN1; SMN2PKMMAPTPOLBGAA | |
| SCHEMBL8311699 | 0.79 | HSPD1 (0.62) | L3MBTL1MAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL7571585 | 0.78 | ALDH1A1 (0.66) | SMN1; SMN2L3MBTL1TDP1PKMIDH1 | |
| SCHEMBL7580547 | 0.78 | IDH1 (0.71) | SMN1; SMN2L3MBTL1IDH1 | |
| SCHEMBL7571566 | 0.78 | SMN1; SMN2 (0.57) | SMN1; SMN2L3MBTL1TDP1PKMNFKBIA | |
| SCHEMBL95317 | 0.78 | SMN1; SMN2 (0.60) | SMN1; SMN2L3MBTL1TDP1NFKBIARELA | |
| SCHEMBL7572373 | 0.77 | L3MBTL1 (0.67) | SMN1; SMN2L3MBTL1TDP1NFKBIARELA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0733626-B1 | N-(Benzofuranazyl)-arylsulphonamides and their analogues useful as endothelin-receptor-antagonists | MERCK PATENT GMBH (DE) | 1999-01-13 | — | — | EP | disclosed |
| US-5726194-A | Endothelin receptor antagonists | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1998-03-10 | — | — | US | disclosed |
| EP-0733626-A1 | N-(Benzofuranazyl)-arylsulphonamides and their analogues useful as endothelin-receptor-antagonists | MERCK PATENT GmbH (DE) | 1996-09-25 | — | — | EP | disclosed |