Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.31 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8578656 | 0.74 | LMNA (0.36) | ALDH1A1LMNACYP3A4CYP2D6CYP2C9 | |
| SCHEMBL3135405 | 0.73 | ALDH1A1 (0.31) | ALDH1A1 | |
| SCHEMBL13952831 | 0.71 | F10 (0.37) | ALDH1A1LMNACYP3A4CYP2D6CYP2C9 | |
| SCHEMBL23827196 | 0.70 | LMNA (0.36) | ALDH1A1LMNACYP3A4CYP2D6CYP2C9 | |
| SCHEMBL7386383 | 0.70 | LMNA (0.36) | ALDH1A1LMNACYP3A4CYP2D6CYP2C9 | |
| SCHEMBL1439742 | 0.69 | LMNA (0.47) | ALDH1A1LMNASOAT1CYP3A4CYP2D6 | |
| SCHEMBL11483266 | 0.69 | ALDH1A1 (0.40) | ALDH1A1LMNASOAT1 | |
| SCHEMBL1634132 | 0.69 | CYP3A4 (0.40) | ALDH1A1LMNACYP3A4CYP2D6CYP2C9 | |
| SCHEMBL21174562 | 0.68 | LMNA (0.34) | ALDH1A1LMNACYP3A4CYP2D6CYP2C9 | |
| SCHEMBL4903389 | 0.67 | HSD11B1 (0.31) | ALDH1A1HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0647637-B1 | 3-Aryl-4-hydroxy-3-dihydrofuranone derivatives | BAYER AG (DE) | 1999-01-27 | — | — | EP | disclosed |
| EP-0647637-A1 | 3-Aryl-4-hydroxy-3-dihydrofuranone derivatives | BAYER AG (DE) | 1995-04-12 | — | — | EP | disclosed |