Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 11/20 | 0.38 |
| ▸ | MMP1 | P03956 | 6/20 | 0.38 |
| ▸ | MMP14 | P50281 | 4/20 | 0.38 |
| ▸ | MMP2 | P08253 | 4/20 | 0.38 |
| ▸ | APP | P05067 | 5/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.33 |
| ▸ | PRKDC | P78527 | 1/20 | 0.33 |
| ▸ | MMP9 | P14780 | 3/20 | 0.32 |
| ▸ | MMP8 | P22894 | 2/20 | 0.32 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.32 |
| ▸ | MMP3 | P08254 | 1/20 | 0.32 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.32 |
| ▸ | HSD17B2 | P37059 | 2/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8321743 | 0.82 | MMP13 (0.57) | MMP13MMP1MMP14MMP2MMP9 | |
| SCHEMBL8320458 | 0.72 | MMP13 (0.39) | MMP13MMP1MMP14MMP2ESR1 | |
| SCHEMBL6207339 | 0.71 | MMP13 (0.49) | MMP13MMP1MMP2MMP9MMP8 | |
| SCHEMBL6206523 | 0.71 | MMP13 (0.53) | MMP13MMP1MMP2MMP9MMP8 | |
| SCHEMBL6206734 | 0.71 | MMP13 (0.70) | MMP13MMP1MMP14MMP2MMP9 | |
| SCHEMBL8316976 | 0.69 | MMP8 (0.53) | MMP13MMP1MMP14MMP2MMP9 | |
| SCHEMBL6231646 | 0.69 | MMP9 (0.38) | MMP13MMP1MMP14MMP2MMP9 | |
| SCHEMBL6697733 | 0.68 | MMP8 (0.54) | MMP13MMP1MMP14MMP2MMP9 | |
| SCHEMBL6227180 | 0.68 | MMP9 (0.40) | MMP13MMP1MMP14MMP2MMP9 | |
| SCHEMBL6228296 | 0.63 | CYP3A4 (0.43) | MMP13MMP1MMP14MMP2MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004048368-A2 | HETEROARYLSULFONYLMETHYL HYDROXAMIC ACIDS AND AMIDES AND THEIR USE AS PROTEASE INHIBITORS | PHARMACIA CORPORATION (US) | 2004-06-10 | — | — | WO | disclosed |