Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 14/20 | 0.39 |
| ▸ | MMP2 | P08253 | 11/20 | 0.39 |
| ▸ | MMP1 | P03956 | 8/20 | 0.39 |
| ▸ | MMP14 | P50281 | 6/20 | 0.39 |
| ▸ | CA12 | O43570 | 2/20 | 0.37 |
| ▸ | CA1 | P00915 | 2/20 | 0.37 |
| ▸ | CA2 | P00918 | 2/20 | 0.37 |
| ▸ | CA9 | Q16790 | 2/20 | 0.37 |
| ▸ | ESR1 | P03372 | 1/20 | 0.35 |
| ▸ | ESRRG | P62508 | 1/20 | 0.35 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.35 |
| ▸ | MMP8 | P22894 | 7/20 | 0.34 |
| ▸ | MMP9 | P14780 | 6/20 | 0.34 |
| ▸ | MMP3 | P08254 | 5/20 | 0.34 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.33 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.33 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6230179 | 0.87 | MMP8 (0.39) | MMP13MMP2MMP1MMP14MMP8 | |
| SCHEMBL6205603 | 0.87 | MMP13 (0.49) | MMP13MMP2MMP1MMP8MMP9 | |
| SCHEMBL6228007 | 0.81 | MMP2 (0.39) | MMP13MMP2MMP1MMP14MMP8 | |
| SCHEMBL8321743 | 0.80 | MMP13 (0.57) | MMP13MMP2MMP1MMP14MMP8 | |
| SCHEMBL8313897 | 0.77 | MMP2 (0.32) | MMP13MMP2MMP1CA12CA1 | |
| SCHEMBL5919374 | 0.75 | MMP13 (0.48) | MMP13MMP2MMP1MMP14MMP8 | |
| SCHEMBL14992966 | 0.74 | MMP13 (0.43) | MMP13MMP2MMP1MMP14CA12 | |
| SCHEMBL5908511 | 0.73 | MMP13 (0.42) | MMP13MMP2MMP1MMP14MMP8 | |
| SCHEMBL8316623 | 0.72 | MMP13 (0.38) | MMP13MMP2MMP1MMP14ESR1 | |
| SCHEMBL5908513 | 0.72 | MMP8 (0.50) | MMP13MMP2MMP1MMP14MMP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004048368-A2 | HETEROARYLSULFONYLMETHYL HYDROXAMIC ACIDS AND AMIDES AND THEIR USE AS PROTEASE INHIBITORS | PHARMACIA CORPORATION (US) | 2004-06-10 | — | — | WO | disclosed |