Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.46 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.33 |
| ▸ | AKT1 | P31749 | 2/20 | 0.32 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.30 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.30 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.30 |
| ▸ | OGFRL1 | Q5TC84 | 1/20 | 0.30 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.30 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.30 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8313986 | 0.88 | BRD4 (0.48) | BRD4BRPF1 | |
| SCHEMBL11403505 | 0.81 | BRD4 (0.34) | BRD4HSD17B10SMN1; SMN2TLR8KMT2A | |
| SCHEMBL11401281 | 0.81 | CA12 (0.36) | BRD4HSD17B10SMN1; SMN2TLR8HCAR1 | |
| SCHEMBL8311751 | 0.77 | BRD4 (0.72) | BRD4BRPF1HSD17B3MEN1GAA | |
| SCHEMBL11397278 | 0.70 | GABRA1 (0.36) | SMN1; SMN2TLR8 | |
| SCHEMBL11397160 | 0.70 | TLR8 (0.46) | BRD4SMN1; SMN2TLR8OPRK1 | |
| SCHEMBL11396744 | 0.69 | CYP11B2 (0.38) | BRD4SMN1; SMN2 | |
| SCHEMBL11402690 | 0.67 | HPGD (0.43) | BRD4HSD17B10SMN1; SMN2TLR8OPRK1 | |
| SCHEMBL14996184 | 0.67 | AVPR1A (0.46) | SMN1; SMN2 | |
| SCHEMBL11777437 | 0.66 | SMN1; SMN2 (0.51) | HSD17B10SMN1; SMN2TLR8MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0536419-B1 | TRICYCLIC TRIAZOLE DERIVATIVES, PRODUCTION AND USE THEREOF | TORAY INDUSTRIES (JP) | 1999-10-13 | — | — | EP | disclosed |
| EP-0536419-A1 | TRICYCLIC TRIAZOLE DERIVATIVE, PRODUCTION THEREOF, AND USE THEREOF | TORAY INDUSTRIES, INC. (JP) | 1993-04-14 | — | — | EP | disclosed |