Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | TYMS | P04818 | 1/20 | 0.45 |
| ▸ | BRD4 | O60885 | 3/20 | 0.45 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.44 |
| ▸ | TNF | P01375 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8459060 | 0.84 | DYRK1A (0.43) | ALDH1A1MAPTLMNAMAPK1SMN1; SMN2 | |
| SCHEMBL8314143 | 0.84 | DYRK1A (0.43) | ALDH1A1MAPTLMNAMAPK1SMN1; SMN2 | |
| SCHEMBL8315901 | 0.82 | ALDH1A1 (0.54) | ALDH1A1MAPTLMNASMN1; SMN2KDM4E | |
| SCHEMBL8316752 | 0.78 | TYMS (0.45) | ALDH1A1MAPTLMNAMAPK1SMN1; SMN2 | |
| SCHEMBL8316587 | 0.77 | ALDH1A1 (0.50) | ALDH1A1MAPTLMNASMN1; SMN2KDM4E | |
| SCHEMBL8312429 | 0.77 | ALDH1A1 (0.47) | ALDH1A1MAPTLMNASMN1; SMN2KDM4E | |
| SCHEMBL2475184 | 0.73 | TYMS (0.46) | ALDH1A1MAPTLMNAMAPK1SMN1; SMN2 | |
| SCHEMBL8311469 | 0.72 | ALDH1A1 (0.37) | ALDH1A1LMNAMAPK1SMN1; SMN2TSHR | |
| SCHEMBL9754273 | 0.72 | FABP4 (0.49) | ALDH1A1MAPTLMNAMAPK1SMN1; SMN2 | |
| SCHEMBL8313452 | 0.71 | ALDH1A1 (0.56) | ALDH1A1MAPTLMNAMAPK1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0609328-B1 | PYRROLO-PYRIDAZINES WITH GASTRO-INTESTINAL PROTECTIVE ACTION | BYK GULDEN LOMBERG CHEM FAB (DE) | 1999-04-28 | — | — | EP | disclosed |
| US-5534515-A | Pyrrolopyridazines having gastrointestinal protective effects | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 1996-07-09 | — | — | US | disclosed |
| WO-1993008190-A1 | PYRROLO-PYRIDAZINES WITH GASTRO-INTESTINAL PROTECTIVE ACTION | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 1993-04-29 | — | — | WO | disclosed |