Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.35 |
| ▸ | WDR5 | P61964 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.32 |
| ▸ | GPR65 | Q8IYL9 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.30 |
| ▸ | ATP4A | P20648 | 2/20 | 0.30 |
| ▸ | ATP4B | P51164 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8316803 | 1.00 | ALDH1A3 (0.35) | ALDH1A3WDR5CA12CA1CA2 | |
| SCHEMBL8317001 | 0.87 | KDM4E (0.42) | POLBMAPTKDM4E | |
| SCHEMBL8317005 | 0.87 | KDM4E (0.42) | POLBMAPTKDM4E | |
| SCHEMBL8315652 | 0.85 | LMNA (0.39) | MAPTKDM4E | |
| SCHEMBL8315650 | 0.85 | LMNA (0.39) | MAPTKDM4E | |
| SCHEMBL8316305 | 0.84 | MAPT (0.42) | POLBMAPTATP4AATP4B | |
| SCHEMBL8316303 | 0.84 | MAPT (0.42) | POLBMAPTATP4AATP4B | |
| SCHEMBL8316004 | 0.83 | FGF23 (0.36) | POLBMAPTKDM4EATP4AATP4B | |
| SCHEMBL8316008 | 0.83 | FGF23 (0.36) | POLBMAPTKDM4EATP4AATP4B | |
| SCHEMBL8313756 | 0.81 | KDM4E (0.34) | MAPTKDM4EATP4AATP4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0351856-B1 | Thiazolo[5,4-b]azepine compounds | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1999-09-15 | — | — | EP | disclosed |
| US-5300639-A | 2-oxo-3-carbonylamino-substituted azepine intermediates; lipoperoxide formation inhibitors | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1994-04-05 | — | — | US | disclosed |
| US-4956360-A | LIPOPEROXIDE INHIBITORS, ENZYME INHIBITORS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1990-09-11 | — | — | US | disclosed |