Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 10/20 | 0.49 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.46 |
| ▸ | MARS1 | P56192 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8422146 | 0.83 | PTGS2 (0.56) | PTGS2CHRNA7PTGS1MAPTHTT | |
| SCHEMBL27714746 | 0.82 | MARS1 (0.59) | MEN1KMT2AMARS1ALDH1A1MAPT | |
| SCHEMBL5694290 | 0.80 | PTGS2 (0.65) | PTGS2PTGS1 | |
| SCHEMBL8643884 | 0.80 | PTGS2 (0.53) | PTGS2PTGS1 | |
| SCHEMBL6308583 | 0.80 | PTGS2 (0.42) | PTGS2CHRNA7MEN1KMT2APTGS1 | |
| Methane SCHEMBL6309289 | 0.79 | PTGS2 (0.47) | PTGS2MEN1KMT2APTGS1MAPT | |
| SCHEMBL8693252 | 0.79 | PTGS2 (0.65) | PTGS2CHRNA7PTGS1 | |
| SCHEMBL27694888 | 0.79 | KMT2A (0.71) | PTGS2CHRNA7MEN1KMT2AMARS1 | |
| SCHEMBL6344501 | 0.79 | PTGS2 (0.76) | PTGS2CHRNA7PTGS1 | |
| SCHEMBL8420732 | 0.78 | PTGS2 (0.51) | PTGS2MEN1KMT2APTGS1MARS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0731795-B1 | SUBSTITUTED PYRAZOLYL BENZENESULFONAMIDES FOR THE TREATMENT OF INFLAMMATION | SEARLE & CO (US) | 1999-12-22 | — | — | EP | disclosed |