Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 14/20 | 0.65 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.41 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.41 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.38 |
| ▸ | CA1 | P00915 | 2/20 | 0.36 |
| ▸ | CA2 | P00918 | 2/20 | 0.36 |
| ▸ | CA9 | Q16790 | 2/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzenesulfonamide SCHEMBL7929456 | 0.95 | PTGS2 (0.68) | PTGS2PTGS1CHRNA7CA1CA2 | |
| SCHEMBL8691511 | 0.90 | PTGS2 (0.51) | PTGS2PTGS1CA1CA2CA9 | |
| SCHEMBL8640732 | 0.88 | PTGS2 (0.50) | PTGS2PTGS1CHRNA7CA2PDPK1 | |
| SCHEMBL8637414 | 0.88 | PTGS2 (0.50) | PTGS2PTGS1CA1CA2CA9 | |
| SCHEMBL8689658 | 0.88 | PTGS2 (0.50) | PTGS2PTGS1CA1CA2CA9 | |
| SCHEMBL8689144 | 0.86 | PTGS2 (0.48) | PTGS2PTGS1CHRNA7CA1CA2 | |
| SCHEMBL8639776 | 0.84 | PTGS2 (0.49) | PTGS2PTGS1CA1CA2CA9 | |
| SCHEMBL8422146 | 0.83 | PTGS2 (0.56) | PTGS2PTGS1CHRNA7CA1CA2 | |
| Sulfamide SCHEMBL7144379 | 0.82 | PTGS2 (0.76) | PTGS2PTGS1NR3C2CHRNA7PDPK1 | |
| SCHEMBL5694290 | 0.80 | PTGS2 (0.65) | PTGS2PTGS1CA1CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5760068-A | NONSTEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS | G.D. SEARLE & CO. (US) | 1998-06-02 | — | — | US | claimed |
| US-5760068-A | NONSTEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS | G.D. SEARLE & CO. (US) | 1998-06-02 | — | — | US | disclosed |
| US-5756529-A | ANTIINFLAMMATORY | G.D. SEARLE & CO. (US) | 1998-05-26 | — | — | US | disclosed |