Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 5/20 | 0.61 |
| ▸ | DRD2 | P14416 | 4/20 | 0.61 |
| ▸ | P2RX7 | Q99572 | 8/20 | 0.59 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.57 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.56 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.56 |
| ▸ | HTR2A | P28223 | 2/20 | 0.56 |
| ▸ | HRH1 | P35367 | 2/20 | 0.56 |
| ▸ | HTR2B | P41595 | 2/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.56 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.56 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.56 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.56 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.56 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.56 |
| ▸ | DRD1 | P21728 | 1/20 | 0.56 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.56 |
| ▸ | HTR2C | P28335 | 1/20 | 0.56 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL28643710 | 0.98 | DRD3 (0.59) | DRD3DRD2P2RX7ADRA1BCHRM2 | |
| SCHEMBL7963339 | 0.90 | DRD3 (0.59) | DRD3DRD2P2RX7CHRM2ADRA2A | |
| Hydrochloric Acid SCHEMBL8311562 | 0.88 | DRD3 (0.58) | DRD3DRD2P2RX7ADRA1BCHRM2 | |
| SCHEMBL7267063 | 0.84 | ACHE (0.69) | DRD3DRD2P2RX7ADRA1BCHRM2 | |
| SCHEMBL7670965 | 0.84 | DRD3 (0.72) | DRD3DRD2CHRM2ADRA2ACYP2D6 | |
| SCHEMBL11938950 | 0.83 | OPRM1 (0.68) | DRD3DRD2P2RX7ADRA1BCHRM2 | |
| SCHEMBL8051388 | 0.83 | DRD3 (0.61) | DRD3DRD2P2RX7ADRA1BCHRM2 | |
| SCHEMBL11206250 | 0.83 | DRD3 (0.61) | DRD3DRD2P2RX7ADRA1BCHRM2 | |
| SCHEMBL4249527 | 0.83 | DRD3 (0.61) | DRD3DRD2P2RX7ADRA1BCHRM2 | |
| SCHEMBL6618656 | 0.83 | DRD3 (0.63) | DRD3DRD2P2RX7ADRA1BCHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-7138236-A | — | — | None | — | — | JP | disclosed |
| EP-3091001-B1 | DIPHENYLMETHYL PIPERAZINE DERIVATIVE AND PHARMACEUTICAL COMPOSITION USING SAME | AETAS PHARMA CO LTD (JP) | 2017-11-22 | — | — | EP | disclosed |
| EP-3091001-B1 | DIPHENYLMETHYL PIPERAZINE DERIVATIVE AND PHARMACEUTICAL COMPOSITION USING SAME | AETAS PHARMA CO LTD (JP) | 2017-11-22 | — | — | EP | disclosed |
| EP-3091001-A1 | DIPHENYLMETHYL PIPERAZINE DERIVATIVE AND PHARMACEUTICAL COMPOSITION USING SAME | Aetas Pharma Co. Ltd. (JP) | 2016-11-09 | — | — | EP | disclosed |
| EP-3091001-A1 | DIPHENYLMETHYL PIPERAZINE DERIVATIVE AND PHARMACEUTICAL COMPOSITION USING SAME | Aetas Pharma Co. Ltd. (JP) | 2016-11-09 | — | — | EP | disclosed |
| EP-2799430-B1 | DIPHENYLMETHYL PIPERAZINE DERIVATIVE AND PHARMACEUTICAL COMPOSITION USING SAME | AETAS PHARMA CO LTD (JP) | 2016-07-20 | — | — | EP | disclosed |
| EP-2799430-B1 | DIPHENYLMETHYL PIPERAZINE DERIVATIVE AND PHARMACEUTICAL COMPOSITION USING SAME | AETAS PHARMA CO LTD (JP) | 2016-07-20 | — | — | EP | disclosed |
| CN-103998428-B | Diphenylmethyl piperazine derivatives and use the medical composition of this derivative | AETAS PHARMA Co.,Ltd. (JP) | 2016-03-23 | — | — | CN | disclosed |
| US-9073861-B2 | Diphenylmethyl piperazine derivative and pharmaceutical composition using same | AETAS PHARMA CO., LTD. (JP) | 2015-07-07 | — | — | US | disclosed |
| US-9073861-B2 | Diphenylmethyl piperazine derivative and pharmaceutical composition using same | AETAS PHARMA CO., LTD. (JP) | 2015-07-07 | — | — | US | disclosed |
| EP-0243905-A1 | 1-(omega-[bis-(phenyl)alkoxy]-alkyl)-4-(di-(phenyl)-methyl)piperazines, process for their preparation and medicines containing them | Richter Gedeon Vegyészeti Gyár R.T. (HU) | 1987-11-04 | — | — | EP | disclosed |
| EP-0115203-B1 | BENZHYDRYLPIPERAZINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Richter Gedeon Vegyészeti Gyár R.T. (HU) | 1987-04-01 | — | — | EP | disclosed |
| US-4504481-A | ENZYME INHIBITORS IN LIVER TO REDUCE TOXIC EFFECT OF DRUGS | RICHTER GEDEON VEGYESZETI GYAR RT. (HU) | 1985-03-12 | — | — | US | disclosed |
| EP-0115203-A1 | Benzhydrylpiperazine derivatives, process for their preparation and pharmaceutical compositions containing them | Richter Gedeon Vegyészeti Gyár R.T. (HU) | 1984-08-08 | — | — | EP | disclosed |
| US-4382934-A | ANTIALLERGENS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1983-05-10 | — | — | US | disclosed |
| EP-0010398-B1 | ISATIN DERIVATIVES, PROCESSES FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1983-04-27 | — | — | EP | disclosed |
| EP-0006506-B1 | CARBOSTYRILE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Roche Diagnostics GmbH (DE) | 1981-09-16 | — | — | EP | disclosed |
| US-4234585-A | ANTIALLERGENS, HYPOTENSIVE | BOEHRINGER MANNHEIM GMBH (DE) | 1980-11-18 | — | — | US | disclosed |
| EP-0010398-A1 | Isatin derivatives, processes for the preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1980-04-30 | — | — | EP | disclosed |
| EP-0006506-A1 | Carbostyrile derivatives, processes for their preparation and pharmaceutical compositions containing them | Roche Diagnostics GmbH (DE) | 1980-01-09 | — | — | EP | disclosed |