Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | F2 | P00734 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.39 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.39 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.39 |
| ▸ | CCR3 | P51677 | 1/20 | 0.38 |
| ▸ | CCR5 | P51681 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8316830 | 0.94 | KMT2A (0.43) | ALDH1A1KMT2ASIGMAR1TSHRMEN1 | |
| SCHEMBL8315832 | 0.87 | KMT2A (0.38) | ALDH1A1KMT2AUTS2RTSHRMAPT | |
| SCHEMBL9538321 | 0.85 | SIGMAR1 (0.49) | ALDH1A1KMT2AUTS2RSIGMAR1TSHR | |
| SCHEMBL8316152 | 0.84 | POLB (0.37) | ALDH1A1KMT2AUTS2RMEN1LMNA | |
| SCHEMBL8877185 | 0.84 | ALDH1A1 (0.47) | ALDH1A1KMT2AUTS2RSIGMAR1TSHR | |
| SCHEMBL8317105 | 0.82 | KMT2A (0.48) | ALDH1A1KMT2ASIGMAR1TSHRMAPT | |
| SCHEMBL8317694 | 0.82 | KMT2A (0.43) | ALDH1A1KMT2ASIGMAR1TSHRMEN1 | |
| SCHEMBL8316844 | 0.80 | KMT2A (0.37) | ALDH1A1KMT2ATSHRMEN1HPGD | |
| SCHEMBL8316358 | 0.80 | KMT2A (0.40) | KMT2ASIGMAR1TSHRMEN1LMNA | |
| SCHEMBL8318856 | 0.79 | KMT2A (0.40) | ALDH1A1KMT2ASIGMAR1TSHRLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0501129-B1 | Substituted bicyclic 3-arylpyrrolidin-2,4-dion derivatives | BAYER AG (DE) | 1999-07-14 | — | — | EP | disclosed |
| EP-0501129-A1 | Substituted bicyclic 3-arylpyrrolidin-2,4-dion derivatives | BAYER AG (DE) | 1992-09-02 | — | — | EP | disclosed |