Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.47 |
| ▸ | DRD1 | P21728 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 3/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | CASP7 | P55210 | 1/20 | 0.39 |
| ▸ | HBB | P68871 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8316443 | 0.94 | KMT2A (0.48) | KMT2AGAASMN1; SMN2MEN1KDM4E | |
| SCHEMBL8315832 | 0.89 | KMT2A (0.38) | KMT2AGAASMN1; SMN2MEN1KDM4E | |
| SCHEMBL8315440 | 0.89 | KMT2A (0.39) | KMT2AGAASMN1; SMN2MEN1KDM4E | |
| SCHEMBL9538257 | 0.84 | KMT2A (0.49) | KMT2AGAASMN1; SMN2MEN1KDM4E | |
| SCHEMBL8875939 | 0.83 | KMT2A (0.55) | KMT2AGAASMN1; SMN2MEN1KDM4E | |
| SCHEMBL8316844 | 0.83 | KMT2A (0.37) | KMT2AGAASMN1; SMN2MEN1KDM4E | |
| SCHEMBL8314913 | 0.83 | KMT2A (0.37) | KMT2AGAAMEN1KDM4EALDH1A1 | |
| SCHEMBL8317467 | 0.82 | ALDH1A1 (0.46) | KMT2AMEN1ALDH1A1TSHRPOLB | |
| SCHEMBL8317229 | 0.82 | KMT2A (0.38) | KMT2AGAASMN1; SMN2MEN1KDM4E | |
| SCHEMBL8315952 | 0.81 | KMT2A (0.47) | KMT2AGAASMN1; SMN2MEN1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0501129-B1 | Substituted bicyclic 3-arylpyrrolidin-2,4-dion derivatives | BAYER AG (DE) | 1999-07-14 | — | — | EP | disclosed |
| EP-0501129-A1 | Substituted bicyclic 3-arylpyrrolidin-2,4-dion derivatives | BAYER AG (DE) | 1992-09-02 | — | — | EP | disclosed |