Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | DRD1 | P21728 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8316844 | 0.94 | KMT2A (0.37) | KMT2AGAAHPGDOPRK1OPRM1 | |
| SCHEMBL8317105 | 0.89 | KMT2A (0.48) | KMT2AGAAALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL8317467 | 0.87 | ALDH1A1 (0.46) | KMT2AHPGDALDH1A1POLBMEN1 | |
| SCHEMBL8314913 | 0.85 | KMT2A (0.37) | KMT2AGAAHPGDOPRM1ALDH1A1 | |
| SCHEMBL9539327 | 0.84 | OPRK1 (0.42) | KMT2AHPGDOPRK1OPRM1SMN1; SMN2 | |
| SCHEMBL8316443 | 0.83 | KMT2A (0.48) | KMT2AGAAHPGDALDH1A1POLB | |
| SCHEMBL8876659 | 0.83 | KMT2A (0.43) | KMT2AGAAHPGDOPRK1OPRM1 | |
| SCHEMBL8315440 | 0.83 | KMT2A (0.39) | KMT2AGAAHPGDALDH1A1POLB | |
| SCHEMBL8310881 | 0.81 | ALDH1A1 (0.39) | KMT2AGAAHPGDOPRK1OPRM1 | |
| SCHEMBL8316830 | 0.80 | KMT2A (0.43) | KMT2AALDH1A1SMN1; SMN2MEN1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0501129-B1 | Substituted bicyclic 3-arylpyrrolidin-2,4-dion derivatives | BAYER AG (DE) | 1999-07-14 | — | — | EP | disclosed |
| EP-0501129-A1 | Substituted bicyclic 3-arylpyrrolidin-2,4-dion derivatives | BAYER AG (DE) | 1992-09-02 | — | — | EP | disclosed |