Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.56 |
| ▸ | TXNRD3 | Q86VQ6 | 1/20 | 0.56 |
| ▸ | TXNRD2 | Q9NNW7 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | EDNRA | P25101 | 1/20 | 0.47 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.46 |
| ▸ | HSPD1 | P10809 | 2/20 | 0.43 |
| ▸ | PTPN2 | P17706 | 2/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.43 |
| ▸ | PTPN5 | P54829 | 2/20 | 0.43 |
| ▸ | HSPE1 | P61604 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | FSCN1 | Q16658 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8311524 | 0.87 | MEN1 (0.56) | TXNRD1TXNRD3TXNRD2MEN1KMT2A | |
| SCHEMBL6762244 | 0.84 | TXNRD1 (0.59) | TXNRD1TXNRD3TXNRD2MEN1KMT2A | |
| SCHEMBL8317641 | 0.81 | EDNRA (0.52) | MEN1KMT2AEDNRAFFAR4HSPD1 | |
| SCHEMBL8313260 | 0.80 | L3MBTL1 (0.64) | TXNRD1TXNRD3TXNRD2MEN1KMT2A | |
| SCHEMBL11407805 | 0.77 | CA2 (0.63) | MEN1KMT2AFFAR4MAPTL3MBTL1 | |
| SCHEMBL8313728 | 0.76 | MEN1 (0.57) | TXNRD1TXNRD3TXNRD2MEN1KMT2A | |
| SCHEMBL6760774 | 0.74 | CDC7 (0.64) | MEN1KMT2AHSPD1PTPN2PTPN1 | |
| SCHEMBL922633 | 0.74 | TXNRD1 (1.00) | TXNRD1TXNRD3TXNRD2MAPTTDP1 | |
| SCHEMBL11772392 | 0.71 | SLC25A1 (0.64) | MEN1KMT2APOLBMAPTNPC1 | |
| SCHEMBL8316242 | 0.71 | SMN1; SMN2 (0.54) | MEN1KMT2APOLBMAPTTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0733626-B1 | N-(Benzofuranazyl)-arylsulphonamides and their analogues useful as endothelin-receptor-antagonists | MERCK PATENT GMBH (DE) | 1999-01-13 | — | — | EP | disclosed |
| US-5726194-A | Endothelin receptor antagonists | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1998-03-10 | — | — | US | disclosed |
| EP-0733626-A1 | N-(Benzofuranazyl)-arylsulphonamides and their analogues useful as endothelin-receptor-antagonists | MERCK PATENT GmbH (DE) | 1996-09-25 | — | — | EP | disclosed |