Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 2/20 | 0.65 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.65 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.65 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.65 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.65 |
| ▸ | MAPT | P10636 | 12/20 | 0.53 |
| ▸ | LMNA | P02545 | 10/20 | 0.53 |
| ▸ | TP53 | P04637 | 9/20 | 0.53 |
| ▸ | THRB | P10828 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | HPGD | P15428 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 3/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8311251 | 1.00 | HTR7 (0.65) | HTR7ADRA2AADRA2BADRA2CNISCH | |
| SCHEMBL4114434 | 0.98 | HTR7 (0.67) | HTR7ADRA2AADRA2BADRA2CNISCH | |
| SCHEMBL5016354 | 0.95 | HTR7 (0.67) | HTR7ADRA2AADRA2BADRA2CNISCH | |
| SCHEMBL4286367 | 0.86 | LMNA (0.67) | MAPTLMNATP53THRBKDM4E | |
| Calcium SCHEMBL29917796 | 0.84 | LMNA (0.65) | MAPTLMNATP53THRBKDM4E | |
| SCHEMBL25189080 | 0.83 | HTR7 (0.81) | HTR7ADRA2AADRA2BADRA2CNISCH | |
| SCHEMBL4279959 | 0.83 | LMNA (0.67) | MAPTLMNATP53THRBKDM4E | |
| SCHEMBL8795254 | 0.82 | HTR7 (0.52) | HTR7ADRA2AADRA2BADRA2CNISCH | |
| SCHEMBL29564708 | 0.81 | CYP2D6 (0.64) | HTR7ADRA2AADRA2BADRA2CNISCH | |
| SCHEMBL25192385 | 0.81 | CYP2D6 (0.64) | HTR7ADRA2AADRA2BADRA2CNISCH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0690050-B1 | (Thia)cycloalkyl(b) indole derivatives as 5-lipoxygenase inhibitors | ADIR (FR) | 1999-11-17 | — | — | EP | disclosed |
| US-5635516-A | SIDE EFFECT REDUCTION | ADIR ET COMPAGNIE (FR) | 1997-06-03 | — | — | US | disclosed |
| EP-0635491-B1 | (Thia) cycloalkyl(b)indoles, process of their preparation and compositions containing it | ADIR (FR) | 1997-05-07 | — | — | EP | disclosed |
| US-5599930-A | Substituted indoles as anti-AIDS pharmaceuticals | THE UPJOHN COMPANY (US) | 1997-02-04 | — | — | US | disclosed |
| EP-0594702-B1 | SUBSTITUTED INDOLES AS ANTI-AIDS PHARMACEUTICALS | UPJOHN CO (US) | 1997-01-29 | — | — | EP | disclosed |
| US-5491163-A | POWERFUL ANTIOXIDANT AND PROTECTS HUMAN LIPIDS, SPECIALLY LOW DENSITY LIPOPROTEINS | ADIR ET COMPAGNIE (FR) | 1996-02-13 | — | — | US | disclosed |
| EP-0690050-A1 | (Thia)cycloalkyl(b) indole derivatives as 5-lipoxygenase inhibitors | ADIR ET COMPAGNIE (FR) | 1996-01-03 | — | — | EP | disclosed |
| EP-0635491-A1 | (Thia) cycloalkyl(b)indoles, process of their preparation and compositions containing it | ADIR ET COMPAGNIE (FR) | 1995-01-25 | — | — | EP | disclosed |
| WO-1993001181-A1 | SUBSTITUTED INDOLES AS ANTI-AIDS PHARMACEUTICALS | THE UPJOHN COMPANY (US) | 1993-01-21 | — | — | WO | disclosed |