Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 4/20 | 0.58 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.58 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.58 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.58 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | JAK2 | O60674 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | TYK2 | P29597 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8324668 | 0.99 | PDE4A (0.59) | PDE4APDE4BPDE4CPDE4DKCNMA1 | |
| SCHEMBL8327236 | 0.86 | MAPT (0.47) | PDE4APDE4BPDE4CPDE4DSMN1; SMN2 | |
| SCHEMBL8324421 | 0.85 | PDE4D (0.44) | PDE4APDE4BPDE4CPDE4DKCNMA1 | |
| SCHEMBL8324954 | 0.85 | PDE4A (0.53) | PDE4APDE4BPDE4CPDE4DKCNMA1 | |
| SCHEMBL8327267 | 0.83 | PDE4A (0.42) | PDE4APDE4BPDE4CPDE4DKCNMA1 | |
| SCHEMBL8319816 | 0.82 | PDE4D (0.63) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL8325303 | 0.81 | PDE4D (0.64) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL8320953 | 0.78 | ALDH1A1 (0.39) | PDE4APDE4BPDE4CPDE4DSMN1; SMN2 | |
| SCHEMBL8320511 | 0.78 | MAPT (0.48) | PDE4APDE4BPDE4CPDE4DKCNMA1 | |
| SCHEMBL8326127 | 0.77 | PDE4D (0.49) | PDE4APDE4BPDE4CPDE4DALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004069831-A1 | TRICYCLIC COMPOUNDS USEFUL FOR THE TREATMENT OF INFLAMMATORY AND ALLERGIC DISORDERS: PROCESS FOR THEIR PREPARATION | GLENMARK PHARMACEUTICALS LTD. (US) | 2004-08-19 | — | — | WO | disclosed |