Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.46 |
| ▸ | TP53 | P04637 | 5/20 | 0.46 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 4/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | RECQL | P46063 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | CASP3 | P42574 | 1/20 | 0.42 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.42 |
| ▸ | RELA | Q04206 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8324668 | 0.87 | PDE4A (0.59) | MAPTTSHRSMN1; SMN2PDE4APDE4B | |
| SCHEMBL8318940 | 0.86 | PDE4A (0.58) | MAPTTSHRSMN1; SMN2PDE4APDE4B | |
| SCHEMBL8325303 | 0.78 | PDE4D (0.64) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL8326127 | 0.78 | PDE4D (0.49) | MAPTTSHRPDE4APDE4BPDE4C | |
| SCHEMBL8319163 | 0.78 | ALDH1A1 (0.39) | MAPTTSHRSMN1; SMN2TP53PDE4A | |
| SCHEMBL8319816 | 0.77 | PDE4D (0.63) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL5025471 | 0.77 | MAPT (0.58) | MAPTTP53PDE4APDE4BPDE4C | |
| SCHEMBL8320953 | 0.77 | ALDH1A1 (0.39) | MAPTTSHRSMN1; SMN2TP53PDE4A | |
| SCHEMBL8324421 | 0.76 | PDE4D (0.44) | MAPTTSHRSMN1; SMN2PDE4APDE4B | |
| SCHEMBL8324954 | 0.74 | PDE4A (0.53) | MAPTSMN1; SMN2PDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004069831-A1 | TRICYCLIC COMPOUNDS USEFUL FOR THE TREATMENT OF INFLAMMATORY AND ALLERGIC DISORDERS: PROCESS FOR THEIR PREPARATION | GLENMARK PHARMACEUTICALS LTD. (US) | 2004-08-19 | — | — | WO | disclosed |