Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 16/20 | 0.49 |
| ▸ | PDE4A | P27815 | 15/20 | 0.49 |
| ▸ | PDE4B | Q07343 | 15/20 | 0.49 |
| ▸ | PDE4C | Q08493 | 15/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8325303 | 0.88 | PDE4D (0.64) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL8319816 | 0.87 | PDE4D (0.63) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL8324668 | 0.78 | PDE4A (0.59) | PDE4DPDE4APDE4BPDE4CMAPT | |
| SCHEMBL8327236 | 0.78 | MAPT (0.47) | PDE4DPDE4APDE4BPDE4CMAPT | |
| SCHEMBL8319163 | 0.78 | ALDH1A1 (0.39) | PDE4DPDE4APDE4BPDE4CMAPT | |
| SCHEMBL8324079 | 0.77 | PDE4D (0.52) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL8318940 | 0.77 | PDE4A (0.58) | PDE4DPDE4APDE4BPDE4CMAPT | |
| SCHEMBL8320953 | 0.77 | ALDH1A1 (0.39) | PDE4DPDE4APDE4BPDE4CMAPT | |
| SCHEMBL8264976 | 0.76 | PDE4D (0.59) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL8319231 | 0.75 | PDE4D (0.58) | PDE4DPDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004069831-A1 | TRICYCLIC COMPOUNDS USEFUL FOR THE TREATMENT OF INFLAMMATORY AND ALLERGIC DISORDERS: PROCESS FOR THEIR PREPARATION | GLENMARK PHARMACEUTICALS LTD. (US) | 2004-08-19 | — | — | WO | disclosed |