Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 1/20 | 0.60 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.53 |
| ▸ | IDO1 | P14902 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | CTRC | Q99895 | 1/20 | 0.51 |
| ▸ | APP | P05067 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | SNCA | P37840 | 1/20 | 0.49 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.45 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.44 |
| ▸ | TAB1 | Q15750 | 1/20 | 0.44 |
| ▸ | MPI | P34949 | 1/20 | 0.43 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8300100 | 0.87 | MAP3K7 (0.62) | NTRK1KDM4EL3MBTL1NPC1RAB9A | |
| SCHEMBL7872417 | 0.87 | MAP3K7 (0.62) | NTRK1KDM4EL3MBTL1NPC1RAB9A | |
| SCHEMBL8325097 | 0.84 | NTRK1 (0.53) | RAF1NTRK1KDM4EL3MBTL1NPC1 | |
| SCHEMBL8318614 | 0.84 | NTRK1 (0.53) | RAF1NTRK1KDM4EL3MBTL1NPC1 | |
| SCHEMBL8321204 | 0.82 | NTRK1 (0.54) | RAF1NTRK1KDM4EL3MBTL1NPC1 | |
| SCHEMBL8099054 | 0.81 | PDPK1 (0.50) | NTRK1KDM4EL3MBTL1NPC1RAB9A | |
| SCHEMBL9047231 | 0.80 | KDM4E (0.49) | RAF1NTRK1KDM4EL3MBTL1NPC1 | |
| SCHEMBL8319627 | 0.80 | NTRK1 (0.62) | RAF1NTRK1MEN1KMT2ACTRC | |
| SCHEMBL8099047 | 0.80 | PLK4 (0.56) | KDM4EL3MBTL1NPC1RAB9ANPSR1 | |
| SCHEMBL8099485 | 0.80 | DHFR (0.52) | NTRK1KDM4EL3MBTL1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0741726-B1 | SUBSTITUTED 3-ARYLIDENE-7-AZAOXINDOLE COMPOUNDS AND PROCESS FOR THEIR PREPARATION | PHARMACIA & UPJOHN SPA (IT) | 1999-11-17 | — | — | EP | claimed |
| EP-0741726-A1 | SUBSTITUTED 3-ARYLIDENE-7-AZAOXINDOLE COMPOUNDS AND PROCESS FOR THEIR PREPARATION | PHARMACIA & UPJOHN S.p.A. (IT) | 1996-11-13 | — | — | EP | claimed |
| WO-1996016964-A1 | SUBSTITUTED 3-ARYLIDENE-7-AZAOXINDOLE COMPOUNDS AND PROCESS FOR THEIR PREPARATION | PHARMACIA & UPJOHN S.P.A (IT) | 1996-06-06 | — | — | WO | claimed |
| EP-0741726-B1 | SUBSTITUTED 3-ARYLIDENE-7-AZAOXINDOLE COMPOUNDS AND PROCESS FOR THEIR PREPARATION | PHARMACIA & UPJOHN SPA (IT) | 1999-11-17 | — | — | EP | disclosed |
| US-5719135-A | TYROSINE KINASE INHIBITORS | PHARMACIA S.P.A. (IT) | 1998-02-17 | — | — | US | disclosed |
| WO-1996016964-A1 | SUBSTITUTED 3-ARYLIDENE-7-AZAOXINDOLE COMPOUNDS AND PROCESS FOR THEIR PREPARATION | PHARMACIA & UPJOHN S.P.A (IT) | 1996-06-06 | — | — | WO | disclosed |