Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.49 |
| ▸ | HTT | P42858 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | RAF1 | P04049 | 1/20 | 0.46 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 3/20 | 0.44 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | BRD4 | O60885 | 5/20 | 0.43 |
| ▸ | CTRC | Q99895 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8319397 | 0.80 | RAF1 (0.60) | KDM4EL3MBTL1NPC1RAB9ARAF1 | |
| SCHEMBL9056804 | 0.76 | KDM4E (0.68) | KDM4EHTTLMNAL3MBTL1NPC1 | |
| SCHEMBL31442525 | 0.76 | KDM4E (0.68) | KDM4EHTTLMNAL3MBTL1NPC1 | |
| SCHEMBL9043235 | 0.76 | CTRC (0.48) | HTTLMNANPC1RAB9AGAA | |
| SCHEMBL9044907 | 0.73 | MAPT (0.46) | NPC1RAB9AGAASMN1; SMN2RAF1 | |
| SCHEMBL9047847 | 0.71 | APP (0.38) | SMN1; SMN2RAF1NTRK1CTRCMAPT | |
| SCHEMBL9044710 | 0.71 | MAPT (0.46) | L3MBTL1NPC1RAB9AGAASMN1; SMN2 | |
| SCHEMBL8321204 | 0.70 | NTRK1 (0.54) | KDM4EL3MBTL1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL31106423 | 0.70 | KDM4E (0.68) | KDM4EHTTLMNAL3MBTL1NPC1 | |
| SCHEMBL6892279 | 0.70 | KDM4E (0.68) | KDM4EHTTLMNAL3MBTL1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0741726-A1 | SUBSTITUTED 3-ARYLIDENE-7-AZAOXINDOLE COMPOUNDS AND PROCESS FOR THEIR PREPARATION | PHARMACIA & UPJOHN S.p.A. (IT) | 1996-11-13 | — | — | EP | disclosed |