Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.48 |
| ▸ | GRM5 | P41594 | 1/20 | 0.46 |
| ▸ | BRS3 | P32247 | 3/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.40 |
| ▸ | KIF11 | P52732 | 1/20 | 0.40 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.38 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.38 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.38 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.38 |
| ▸ | KDM6B | O15054 | 1/20 | 0.38 |
| ▸ | KDM4A | O75164 | 1/20 | 0.38 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.38 |
| ▸ | KDM3B | Q7LBC6 | 1/20 | 0.38 |
| ▸ | HIF1AN | Q9NWT6 | 1/20 | 0.38 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.38 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29356218 | 0.89 | SLC7A5 (0.51) | CYP3A4SLC7A5CYP1A2RECQLSLC1A3 | |
| Methylamine SCHEMBL29022748 | 0.86 | CYP3A4 (0.46) | CYP3A4SLC7A5GRM5SLC1A3GRIA1 | |
| SCHEMBL849758 | 0.83 | SLC7A5 (0.51) | CYP3A4SLC7A5CYP1A2SLC1A3GRIA1 | |
| SCHEMBL20539892 | 0.82 | ARG2 (0.46) | CYP3A4SLC7A5SLC1A3GRIA1GRIA2 | |
| SCHEMBL29022740 | 0.81 | SLC7A5 (0.47) | CYP3A4SLC7A5BRS3SLC1A3GRIA1 | |
| SCHEMBL27446953 | 0.80 | SLC7A5 (0.51) | CYP3A4SLC7A5CYP1A2RECQLSLC1A3 | |
| SCHEMBL8326405 | 0.79 | BRS3 (0.42) | BRS3 | |
| SCHEMBL5292853 | 0.78 | SLC7A5 (0.53) | CYP3A4SLC7A5CYP1A2SLC1A3GRIA1 | |
| SCHEMBL1539194 | 0.78 | SLC7A5 (0.53) | CYP3A4SLC7A5CYP1A2SLC1A3GRIA1 | |
| SCHEMBL26912795 | 0.78 | SLC7A5 (0.53) | CYP3A4SLC7A5CYP1A2SLC1A3GRIA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0589665-B1 | 4,5,6,7-Tetrahydro-1H-imidazo 4,5-c pyridine-6-carboxylic acid amide derivatives as angiotensine II antagonistes | KUREHA CHEMICAL IND CO LTD (JP) | 1999-11-17 | — | — | EP | disclosed |
| US-5401736-A | Angiotensis II antagonists | KUREHA KAGAKU KOGYO KABUSHIKI KAISHA (JP) | 1995-03-28 | — | — | US | disclosed |
| EP-0589665-A2 | 4,5,6,7-Tetrahydro-1H-imidazo 4,5-c pyridine-6-carboxylic acid amide derivatives as angiotensine II antagonistes | KUREHA KAGAKU KOGYO KABUSHIKI KAISHA (JP) | 1994-03-30 | — | — | EP | disclosed |