Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 7/20 | 0.55 |
| ▸ | RORC | P51449 | 4/20 | 0.52 |
| ▸ | CASP6 | P55212 | 1/20 | 0.51 |
| ▸ | GFER | P55789 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.50 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1911851 | 0.84 | TGFBR1 (0.54) | ALKCASP6GFERMAPTLMNA | |
| SCHEMBL19002643 | 0.84 | GFER (0.53) | ALKCASP6GFERMAPTLMNA | |
| SCHEMBL12312214 | 0.83 | CASP6 (0.59) | ALKCASP6GFERMAPTLMNA | |
| SCHEMBL31195734 | 0.83 | ALK (0.55) | ALKMAPTLMNAALDH1A1 | |
| SCHEMBL4281721 | 0.81 | QDPR (0.59) | ALKCASP6GFERMAPTLMNA | |
| SCHEMBL1911902 | 0.81 | TGFBR1 (0.54) | ALKCASP6GFERMAPTLMNA | |
| SCHEMBL5262415 | 0.81 | GFER (0.55) | RORCCASP6GFERMAPTKDM4E | |
| SCHEMBL8324354 | 0.81 | LMNA (0.44) | ALKGFERMAPTLMNAKDM4E | |
| SCHEMBL3315825 | 0.81 | CASP6 (0.49) | ALKRORCCASP6GFERMAPT | |
| SCHEMBL12856227 | 0.81 | MAPT (0.49) | ALKCASP6GFERMAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1592426-B1 | 2-CYANOPYRROLOPYRIMIDINES AND PHARMACEUTICAL USES THEREOF | NOVARTIS AG (CH) | 2007-12-19 | — | — | EP | disclosed |
| WO-2004069256-A1 | 2-CYANOPYRROLOPYRIMIDINES AND PHARMACEUTICAL USES THEREOF | NOVARTIS AG (CH) | 2004-08-19 | — | — | WO | disclosed |