Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 1/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.47 |
| ▸ | BLM | P54132 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | ESR1 | P03372 | 1/20 | 0.47 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.47 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.47 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | GGT1 | P19440 | 1/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.47 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.47 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL544041 | 0.86 | ACHE (0.69) | ACHEMAPK1KDM4EHSD17B10HPGD | |
| SCHEMBL459655 | 0.82 | PTGS2 (0.57) | ACHEMAPK1KDM4EHSD17B10HPGD | |
| SCHEMBL31229899 | 0.80 | ACHE (0.62) | ACHEMAPK1KDM4EHSD17B10HPGD | |
| SCHEMBL742810 | 0.80 | ACHE (0.62) | ACHEMAPK1KDM4EHSD17B10HPGD | |
| SCHEMBL907658 | 0.78 | ACHE (0.61) | ACHEMAPK1KDM4EHSD17B10HPGD | |
| SCHEMBL544758 | 0.78 | ACHE (0.61) | ACHEMAPK1KDM4EHSD17B10HPGD | |
| SCHEMBL11585900 | 0.78 | ACHE (0.61) | ACHEMAPK1KDM4EHSD17B10HPGD | |
| SCHEMBL544172 | 0.78 | ACHE (0.61) | ACHEMAPK1KDM4EHSD17B10HPGD | |
| SCHEMBL21728175 | 0.77 | ACHE (0.59) | ACHEMAPK1KDM4EHSD17B10HPGD | |
| SCHEMBL868843 | 0.77 | ACHE (0.59) | ACHEMAPK1KDM4EHSD17B10HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103958523-A | Piperazin-1-yl compounds as dual activity H1 inverse agonist/5-HT2Aantagonists (thieno [2,3-b] [1,5] benzoxaza-4-yl) | LILLY CO ELI | 2014-07-30 | — | — | CN | disclosed |
| CN-101084222-A | Synthesis of 2-methyl-4-(4-methyl-1-piperazinyl)-10h-thieno[2, 3-b][1,5]benzodiazepine and salts thereof | LEK PHARMACEUTICALS (SI) | 2007-12-05 | — | — | CN | disclosed |
| EP-0931074-A1 | CONDENSED 4,5,6,7-TETRAHYDROBENZO C]THIOPHENES AS ENHANCER FOR CELL DIFFERENTIATION INDUCTION FACTOR ACTION | Takeda Chemical Industries, Ltd. (JP) | 1999-07-28 | — | — | EP | disclosed |
| WO-1998009958-A1 | CONDENSED 4,5,6,7-TETRAHYDROBENZO[C]THIOPHENES AS ENHANCER FOR CELL DIFFERENTIATION INDUCTION FACTOR ACTION | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-03-12 | — | — | WO | disclosed |