Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1D | P25100 | 10/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 10/20 | 0.46 |
| ▸ | ADRA1B | P35368 | 10/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6197822 | 1.00 | ADRA1D (0.46) | ADRA1DADRA1AADRA1BATMALDH1A1 | |
| SCHEMBL6199093 | 0.88 | ADRA1D (0.42) | ADRA1DADRA1AADRA1BATMALDH1A1 | |
| SCHEMBL6196678 | 0.87 | ALDH1A1 (0.37) | ADRA1DADRA1AADRA1BALDH1A1LMNA | |
| SCHEMBL6193377 | 0.84 | ADRA1D (0.42) | ADRA1DADRA1AADRA1BATMALDH1A1 | |
| SCHEMBL6199413 | 0.82 | PKM (0.52) | ATMALDH1A1TSHRGAA | |
| SCHEMBL19752687 | 0.77 | GUSB (0.64) | ALDH1A1LMNATSHRGAAL3MBTL1 | |
| SCHEMBL19752623 | 0.77 | GUSB (0.64) | ALDH1A1LMNATSHRGAAL3MBTL1 | |
| SCHEMBL8196075 | 0.76 | ADRA1A (0.37) | ADRA1DADRA1AADRA1BATM | |
| SCHEMBL10113415 | 0.76 | TP53 (0.70) | ADRA1DADRA1AADRA1BALDH1A1LMNA | |
| SCHEMBL6196948 | 0.74 | GAA (0.36) | ADRA1DADRA1AADRA1BALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0866708-A4 | DIHYDROPYRIMIDINES AND USES THEREOF | SYNAPTIC PHARMA CORP (US) | 1999-05-06 | — | — | EP | disclosed |
| EP-0866708-A1 | DIHYDROPYRIMIDINES AND USES THEREOF | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 1998-09-30 | — | — | EP | disclosed |
| WO-1997017969-A1 | DIHYDROPYRIMIDINES AND USES THEREOF | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 1997-05-22 | — | — | WO | disclosed |