Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | SMO | Q99835 | 2/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8625320 | 0.82 | KDM4E (0.54) | KDM4EALDH1A1MAPTGPR119MEN1 | |
| Ammonia Solution, Strong SCHEMBL4429607 | 0.82 | KDM4E (0.55) | KDM4EALDH1A1MAPTGPR119MEN1 | |
| SCHEMBL14127580 | 0.80 | PDE10A (0.44) | MAPTGPR119SMO | |
| SCHEMBL8508214 | 0.79 | GPR119 (0.54) | KDM4EALDH1A1MAPTGPR119MEN1 | |
| SCHEMBL8320676 | 0.77 | KDM4E (0.58) | KDM4EALDH1A1MAPTGPR119MEN1 | |
| SCHEMBL2146862 | 0.77 | GPR119 (0.49) | KDM4EALDH1A1MAPTGPR119MEN1 | |
| SCHEMBL2146968 | 0.77 | GPR119 (0.49) | KDM4EALDH1A1MAPTGPR119MEN1 | |
| SCHEMBL2146859 | 0.77 | GPR119 (0.49) | KDM4EALDH1A1MAPTGPR119MEN1 | |
| SCHEMBL28662011 | 0.77 | ADRB2 (0.49) | KDM4EALDH1A1LMNA | |
| SCHEMBL8329851 | 0.75 | KDM4E (0.48) | KDM4EALDH1A1MAPTGPR119SMO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3049391-B1 | INDOLE AND INDAZOLE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2018-12-26 | — | — | EP | disclosed |
| US-5919782-A | CONTAINING A 2,4-DIOXOTRIAZOLIDINE RING | DR. REDDY'S RESEARCH FOUNDATION (IN) | 1999-07-06 | — | — | US | disclosed |
| US-5801173-A | Heterocyclic compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them | DR. REDDY'S RESEARCH FOUNDATION (IN) | 1998-09-01 | — | — | US | disclosed |