Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | PDE8B | O95263 | 1/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.38 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11242354 | 0.82 | RAB9A (0.55) | SMN1; SMN2LMNAHTTCYP3A4CYP2C9 | |
| SCHEMBL509951 | 0.79 | ALOX5 (0.44) | SMN1; SMN2LMNAMEN1KMT2ARAB9A | |
| SCHEMBL1712058 | 0.79 | KMT2A (0.41) | SMN1; SMN2CYP2C9CYP2C19MEN1KMT2A | |
| SCHEMBL31372334 | 0.77 | DRD4 (0.53) | SMN1; SMN2LMNACYP3A4CYP2C9MEN1 | |
| SCHEMBL29196462 | 0.77 | DRD4 (0.53) | SMN1; SMN2LMNACYP3A4CYP2C9MEN1 | |
| SCHEMBL509467 | 0.76 | ALDH1A1 (0.43) | SMN1; SMN2LMNAMEN1KMT2AL3MBTL1 | |
| SCHEMBL19478479 | 0.75 | TNK2 (0.37) | SMN1; SMN2LMNAHTTCYP3A4CYP2C9 | |
| SCHEMBL11748289 | 0.75 | KMT2A (0.40) | SMN1; SMN2CYP2C9CYP2C19MEN1KMT2A | |
| SCHEMBL16059598 | 0.74 | SMN1; SMN2 (0.59) | SMN1; SMN2LMNAHTTMEN1KMT2A | |
| SCHEMBL29173256 | 0.74 | LOXL2 (0.43) | CYP3A4CYP2C9CYP2C19TDP1HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0687267-B1 | PYRROLO-PYRIDINE DERIVATIVES AS LIGANDS OF DOPAMINE RECEPTOR | MERCK SHARP & DOHME (GB) | 1999-09-01 | — | — | EP | disclosed |
| US-5700809-A | Pyrrolo-pyridine derivatives | MERCK SHARP & DOHME, LTD. (GB) | 1997-12-23 | — | — | US | disclosed |
| EP-0687267-A1 | PYRROLO-PYRIDINE DERIVATIVES | MERCK SHARP & DOHME LTD. (GB) | 1995-12-20 | — | — | EP | disclosed |
| WO-1994020459-A2 | PYRROLO-PYRIDINE DERIVATIVES AS DOPAMINE RECEPTOR LIGANDS | MERCK SHARP & DOHME LIMITED (GB) | 1994-09-15 | — | — | WO | disclosed |