Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.67 |
| ▸ | ACHE | P22303 | 3/20 | 0.60 |
| ▸ | GABRA1 | P14867 | 4/20 | 0.58 |
| ▸ | GABRA2 | P47869 | 4/20 | 0.58 |
| ▸ | CLPP | Q16740 | 1/20 | 0.56 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.55 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.53 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.53 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8323565 | 0.99 | HPGD (0.65) | HPGDACHEGABRA1GABRA2CLPP | |
| SCHEMBL22028762 | 0.94 | CLPP (0.60) | HPGDACHEGABRA1GABRA2CLPP | |
| SCHEMBL22071231 | 0.93 | KDM4E (0.62) | HPGDACHEGABRA1GABRA2CLPP | |
| SCHEMBL22028736 | 0.90 | CLPP (0.62) | HPGDACHEGABRA1GABRA2CLPP | |
| SCHEMBL22028733 | 0.90 | ACHE (0.58) | HPGDACHEGABRA1GABRA2CLPP | |
| SCHEMBL8323169 | 0.87 | ACHE (0.57) | ACHEGABRA1GABRA2SLC6A5GABRA5 | |
| Hydrochloric Acid SCHEMBL8323662 | 0.86 | ACHE (0.56) | ACHEGABRA1GABRA2SLC6A5GABRA5 | |
| Hydrochloric Acid SCHEMBL8323549 | 0.84 | HPGD (0.64) | HPGDACHEGABRA1GABRA2CLPP | |
| SCHEMBL8324851 | 0.80 | ACHE (0.55) | ACHEGABRA1GABRA2SLC6A5GABRA5 | |
| SCHEMBL2625346 | 0.80 | SLC6A5 (0.80) | ACHEGABRA1GABRA2CLPPSLC6A5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0621037-B1 | Pyrido-pyrimidinediones, process for their preparation and their use as pharmaceuticals | HOECHST AG (DE) | 1999-07-07 | — | — | EP | disclosed |
| US-5556854-A | CARDIOVASCULAR DISORDERS AND/OR NEUROGENERATIVE DISORDERS | HOECHST AKTIENGESELLSCHAFT (DE) | 1996-09-17 | — | — | US | disclosed |
| EP-0621037-A1 | Pyrido-pyrimidinediones, process for their preparation and their use as pharmaceuticals | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-10-26 | — | — | EP | disclosed |