Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 4/20 | 0.57 |
| ▸ | GABRA1 | P14867 | 5/20 | 0.56 |
| ▸ | GABRA2 | P47869 | 5/20 | 0.56 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.54 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.54 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8323662 | 0.99 | ACHE (0.56) | ACHEGABRA1GABRA2GABRA5GABRA3 | |
| SCHEMBL8324851 | 0.88 | ACHE (0.55) | ACHEGABRA1GABRA2GABRA5GABRA3 | |
| SCHEMBL8322947 | 0.87 | HPGD (0.67) | ACHEGABRA1GABRA2GABRA5GABRA3 | |
| Hydrochloric Acid SCHEMBL8323565 | 0.86 | HPGD (0.65) | ACHEGABRA1GABRA2GABRA5GABRA3 | |
| SCHEMBL22071231 | 0.83 | KDM4E (0.62) | ACHEGABRA1GABRA2GABRA5GABRA3 | |
| SCHEMBL2303143 | 0.82 | ACHE (0.53) | ACHEGABRA1GABRA2GABRA5GABRA3 | |
| SCHEMBL22028762 | 0.81 | CLPP (0.60) | ACHEGABRA1GABRA2GABRA5GABRA3 | |
| SCHEMBL22028733 | 0.80 | ACHE (0.58) | ACHEGABRA1GABRA2GABRA5GABRA3 | |
| SCHEMBL8319246 | 0.80 | SLC6A5 (0.56) | ACHEGABRA1GABRA2SLC6A5KDM4E | |
| SCHEMBL8319661 | 0.79 | CLPP (0.54) | ACHEKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0621037-B1 | Pyrido-pyrimidinediones, process for their preparation and their use as pharmaceuticals | HOECHST AG (DE) | 1999-07-07 | — | — | EP | disclosed |
| US-5556854-A | CARDIOVASCULAR DISORDERS AND/OR NEUROGENERATIVE DISORDERS | HOECHST AKTIENGESELLSCHAFT (DE) | 1996-09-17 | — | — | US | disclosed |
| EP-0621037-A1 | Pyrido-pyrimidinediones, process for their preparation and their use as pharmaceuticals | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-10-26 | — | — | EP | disclosed |