Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 14/20 | 0.54 |
| ▸ | HDAC8 | Q9BY41 | 11/20 | 0.54 |
| ▸ | HDAC3 | O15379 | 9/20 | 0.54 |
| ▸ | HDAC2 | Q92769 | 9/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 7/20 | 0.54 |
| ▸ | HDAC4 | P56524 | 6/20 | 0.54 |
| ▸ | HDAC7 | Q8WUI4 | 6/20 | 0.54 |
| ▸ | HDAC10 | Q969S8 | 6/20 | 0.54 |
| ▸ | HDAC11 | Q96DB2 | 6/20 | 0.54 |
| ▸ | HDAC9 | Q9UKV0 | 6/20 | 0.54 |
| ▸ | HDAC5 | Q9UQL6 | 6/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8322760 | 0.88 | TBXAS1 (0.48) | HDAC1HDAC8HDAC3HDAC2HDAC6 | |
| SCHEMBL8324028 | 0.84 | NR1H4 (0.40) | HDAC1HDAC8HDAC3HDAC2HDAC6 | |
| SCHEMBL8327745 | 0.77 | HDAC2 (0.56) | HDAC1HDAC8HDAC3HDAC2HDAC6 | |
| SCHEMBL8320427 | 0.76 | HDAC2 (0.56) | HDAC1HDAC8HDAC3HDAC2HDAC6 | |
| SCHEMBL8323117 | 0.74 | HDAC1 (0.52) | HDAC1HDAC8HDAC3HDAC2HDAC6 | |
| SCHEMBL8320562 | 0.72 | HDAC1 (0.61) | HDAC1HDAC8HDAC3HDAC2HDAC6 | |
| SCHEMBL24925531 | 0.70 | HDAC1 (0.49) | HDAC1HDAC8HDAC3HDAC2HDAC6 | |
| SCHEMBL4631676 | 0.70 | HDAC1 (1.00) | HDAC1HDAC8HDAC3HDAC2HDAC6 | |
| SCHEMBL4631682 | 0.70 | HDAC1 (1.00) | HDAC1HDAC8HDAC3HDAC2HDAC6 | |
| SCHEMBL8320552 | 0.70 | HDAC1 (0.73) | HDAC1HDAC8HDAC3HDAC2HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004063169-A1 | HYDROXAMID ACID DERIVATIVES AS HISTONE DEACETYLASE (HDAC) INHIBITORS | ASTELLAS PHARMA INC. (JP) | 2004-07-29 | — | — | WO | disclosed |