Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXAS1 | P24557 | 4/20 | 0.48 |
| ▸ | BRS3 | P32247 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | MITF | O75030 | 1/20 | 0.44 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.44 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.43 |
| ▸ | CYP26B1 | Q9NR63 | 1/20 | 0.43 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | CASP3 | P42574 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.42 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.42 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8323151 | 0.88 | HDAC1 (0.54) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL8324028 | 0.86 | NR1H4 (0.40) | TBXAS1BRS3HDAC3HDAC4HDAC1 | |
| SCHEMBL8319501 | 0.75 | THRB (0.54) | TBXAS1BRS3KDM4EALDH1A1HPGD | |
| SCHEMBL8322805 | 0.74 | BRS3 (0.48) | TBXAS1BRS3KDM4EALDH1A1HPGD | |
| SCHEMBL8324034 | 0.73 | RECQL (0.45) | TBXAS1BRS3KDM4EALDH1A1HPGD | |
| SCHEMBL8921111 | 0.72 | TBXAS1 (0.68) | TBXAS1KDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL9401700 | 0.72 | TAAR1 (0.55) | TBXAS1KDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL9507338 | 0.72 | TAAR1 (0.55) | TBXAS1KDM4EALDH1A1HPGDSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL7266355 | 0.71 | TBXAS1 (0.54) | TBXAS1KDM4EALDH1A1HPGDSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL11261045 | 0.70 | TBXAS1 (0.53) | TBXAS1KDM4EALDH1A1HPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004063169-A1 | HYDROXAMID ACID DERIVATIVES AS HISTONE DEACETYLASE (HDAC) INHIBITORS | ASTELLAS PHARMA INC. (JP) | 2004-07-29 | — | — | WO | disclosed |