Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.55 |
| ▸ | NPC1 | O15118 | 6/20 | 0.55 |
| ▸ | RAB9A | P51151 | 6/20 | 0.55 |
| ▸ | RECQL | P46063 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 4/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.46 |
| ▸ | CASR | P41180 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8327647 | 0.90 | NPC1 (0.61) | SMN1; SMN2NPC1RAB9ARECQLLMNA | |
| SCHEMBL19011398 | 0.78 | SMN1; SMN2 (0.58) | SMN1; SMN2NPC1RAB9ARECQLLMNA | |
| SCHEMBL10597471 | 0.78 | RAB9A (0.77) | SMN1; SMN2NPC1RAB9ARECQLLMNA | |
| SCHEMBL8319439 | 0.77 | RAB9A (0.56) | SMN1; SMN2NPC1RAB9ARECQLLMNA | |
| SCHEMBL8319913 | 0.77 | LMNA (0.54) | SMN1; SMN2NPC1RAB9ARECQLLMNA | |
| SCHEMBL10817231 | 0.76 | RAB9A (0.75) | SMN1; SMN2NPC1RAB9ARECQLLMNA | |
| SCHEMBL17263428 | 0.76 | RAB9A (0.75) | SMN1; SMN2NPC1RAB9ARECQLLMNA | |
| SCHEMBL10595749 | 0.76 | LMNA (0.65) | SMN1; SMN2NPC1RAB9ARECQLLMNA | |
| SCHEMBL3765824 | 0.75 | RAB9A (0.69) | SMN1; SMN2NPC1RAB9ARECQLLMNA | |
| SCHEMBL7980669 | 0.75 | NPC1 (0.80) | SMN1; SMN2NPC1RAB9ARECQLLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5977170-A | HIGH DENISTY LIPOPROTEINS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-11-02 | — | — | US | disclosed |
| WO-1998057927-A1 | ELEVATION OF HDL CHOLESTEROL BY 4-[(AMINOTHIOXOMETHYL)HYDRAZONO]-4-ARYLBUTYL CARBAMATES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-12-23 | — | — | WO | disclosed |