Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 7/20 | 0.61 |
| ▸ | RAB9A | P51151 | 7/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.61 |
| ▸ | RECQL | P46063 | 1/20 | 0.61 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.51 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | KLK7 | P49862 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8323233 | 0.90 | SMN1; SMN2 (0.55) | NPC1RAB9ASMN1; SMN2RECQLTSHR | |
| SCHEMBL8319913 | 0.85 | LMNA (0.54) | NPC1RAB9ASMN1; SMN2RECQLLMNA | |
| SCHEMBL10597471 | 0.84 | RAB9A (0.77) | NPC1RAB9ASMN1; SMN2RECQLTSHR | |
| SCHEMBL17263428 | 0.82 | RAB9A (0.75) | NPC1RAB9ASMN1; SMN2RECQLTSHR | |
| SCHEMBL10817231 | 0.82 | RAB9A (0.75) | NPC1RAB9ASMN1; SMN2RECQLTSHR | |
| SCHEMBL8323364 | 0.81 | CHRM3 (0.50) | NPC1RAB9ASMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL8323008 | 0.80 | ALDH1A1 (0.58) | NPC1RAB9ASMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL15809660 | 0.79 | POLB (0.55) | NPC1RAB9ASMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL10817742 | 0.79 | RAB9A (0.58) | NPC1RAB9ASMN1; SMN2RECQLTSHR | |
| SCHEMBL15809658 | 0.79 | POLB (0.55) | NPC1RAB9ASMN1; SMN2LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5977170-A | HIGH DENISTY LIPOPROTEINS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-11-02 | — | — | US | disclosed |
| WO-1998057927-A1 | ELEVATION OF HDL CHOLESTEROL BY 4-[(AMINOTHIOXOMETHYL)HYDRAZONO]-4-ARYLBUTYL CARBAMATES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-12-23 | — | — | WO | disclosed |