Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STK10 | O94804 | 1/20 | 0.41 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.41 |
| ▸ | TNKS | O95271 | 1/20 | 0.41 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.41 |
| ▸ | PRKDC | P78527 | 4/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | TDP2 | O95551 | 1/20 | 0.38 |
| ▸ | STK4 | Q13043 | 1/20 | 0.38 |
| ▸ | STK3 | Q13188 | 1/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7201836 | 0.73 | CA12 (0.34) | STK10SLKMAPTALDH1A1KDM4E | |
| SCHEMBL7296783 | 0.73 | DDB1 (0.37) | TNKSTNKS2ALDH1A1 | |
| SCHEMBL7293888 | 0.72 | CA12 (0.35) | MAPTALDH1A1KDM4ERAB9ALMNA | |
| SCHEMBL7303598 | 0.72 | CA12 (0.35) | MAPTALDH1A1KDM4ERAB9ALMNA | |
| SCHEMBL627191 | 0.71 | RAB9A (0.35) | STK10SLKNPC1ALDH1A1KDM4E | |
| SCHEMBL7303932 | 0.70 | ALDH1A1 (0.40) | NPC1MAPTALDH1A1KDM4ERAB9A | |
| SCHEMBL7330474 | 0.69 | MAPT (0.33) | MAPTALDH1A1KDM4ELMNAHPGD | |
| SCHEMBL7297774 | 0.69 | FYN (0.39) | MAPTALDH1A1KDM4ELMNASMN1; SMN2 | |
| SCHEMBL7209808 | 0.68 | CA2 (0.46) | STK10SLKMAPTALDH1A1KDM4E | |
| SCHEMBL7293097 | 0.67 | STK10 (0.40) | STK10SLKMAPK1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0633259-B1 | Sulfonylaminopyrimidines, their preparation and their use as medicine | HOFFMANN LA ROCHE (CH) | 1999-01-13 | — | — | EP | disclosed |
| US-5541186-A | ENDOTHELIN RECEPTOR INHIBITORS | HOFFMANN-LA ROCHE INC. (US) | 1996-07-30 | — | — | US | disclosed |
| EP-0633259-A1 | Sulfonylaminopyrimidines, their preparation and their use as medicine | F. HOFFMANN-LA ROCHE AG (CH) | 1995-01-11 | — | — | EP | disclosed |