Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 2/20 | 0.55 |
| ▸ | HTR2A | P28223 | 1/20 | 0.55 |
| ▸ | HTR2C | P28335 | 1/20 | 0.55 |
| ▸ | DRD3 | P35462 | 1/20 | 0.55 |
| ▸ | HTR7 | P34969 | 2/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.52 |
| ▸ | DRD4 | P21917 | 3/20 | 0.50 |
| ▸ | DRD2 | P14416 | 1/20 | 0.50 |
| ▸ | FAAH | O00519 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.46 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.46 |
| ▸ | CYBB | P04839 | 1/20 | 0.45 |
| ▸ | NOX4 | Q9NPH5 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Centhaquine SCHEMBL10029638 | 0.88 | DRD3 (0.58) | HTR1AHTR2AHTR2CDRD3HTR7 | |
| Centhaquine SCHEMBL29751033 | 0.88 | DRD3 (0.58) | HTR1AHTR2AHTR2CDRD3HTR7 | |
| Centhaquine SCHEMBL29991817 | 0.88 | DRD3 (0.58) | HTR1AHTR2AHTR2CDRD3HTR7 | |
| Centhaquine SCHEMBL11788684 | 0.87 | DRD3 (0.57) | HTR1AHTR2AHTR2CDRD3HTR7 | |
| SCHEMBL8323715 | 0.86 | SLC6A4 (0.54) | HTR1ADRD3HTR7DRD4DRD2 | |
| SCHEMBL27609044 | 0.85 | DRD4 (0.62) | HTR1AHTR2AHTR2CDRD3HTR7 | |
| SCHEMBL8322802 | 0.83 | DRD4 (0.50) | HTR1AHTR2ADRD3HTR7DRD4 | |
| SCHEMBL1331198 | 0.81 | FAAH (0.65) | HTR1AHTR7DRD4FAAHMAPT | |
| SCHEMBL17289123 | 0.81 | FAAH (0.65) | HTR1AHTR7DRD4FAAHMAPT | |
| SCHEMBL8320500 | 0.78 | HTR1A (0.47) | HTR1ADRD3HTR7DRD4DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5945421-A | TREATING PSYCHOSIS AND SCHIZOPHRENIA | WARNER-LAMBERT COMPANY (US) | 1999-08-31 | — | — | US | disclosed |