Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 7/20 | 0.58 |
| ▸ | HTR1A | P08908 | 5/20 | 0.58 |
| ▸ | HTR2A | P28223 | 4/20 | 0.58 |
| ▸ | HTR2C | P28335 | 4/20 | 0.58 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.56 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.48 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.48 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.48 |
| ▸ | DRD1 | P21728 | 1/20 | 0.48 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.48 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.48 |
| ▸ | HRH1 | P35367 | 1/20 | 0.47 |
| ▸ | HTR7 | P34969 | 2/20 | 0.46 |
| ▸ | DRD2 | P14416 | 4/20 | 0.46 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.44 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Centhaquine SCHEMBL10029638 | 1.00 | DRD3 (0.58) | DRD3HTR1AHTR2AHTR2CKCNH2 | |
| Centhaquine SCHEMBL29751033 | 1.00 | DRD3 (0.58) | DRD3HTR1AHTR2AHTR2CKCNH2 | |
| Centhaquine SCHEMBL11788684 | 0.99 | DRD3 (0.57) | DRD3HTR1AHTR2AHTR2CKCNH2 | |
| SCHEMBL8323587 | 0.88 | HTR1A (0.55) | DRD3HTR1AHTR2AHTR2CKCNH2 | |
| Centhaquine SCHEMBL29991187 | 0.87 | DRD3 (0.56) | DRD3HTR1AHTR2AHTR2CKCNH2 | |
| SCHEMBL11786229 | 0.86 | MAPT (0.59) | DRD3HTR1AHTR2AHTR2CADRA1A | |
| SCHEMBL11785894 | 0.86 | DRD2 (0.56) | DRD3HTR1AHTR2AHTR2CKCNH2 | |
| SCHEMBL27590575 | 0.86 | HTR1A (0.60) | DRD3HTR1AHTR2AHTR2CKCNH2 | |
| SCHEMBL11786467 | 0.86 | DRD3 (0.48) | DRD3HTR1AHTR2AHTR2CKCNH2 | |
| SCHEMBL11784684 | 0.86 | SIGMAR1 (0.62) | DRD3HTR1AKCNH2ADRA1ASLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4337209-A1 | PHARMACEUTICAL COMPOSITION AND METHOD FOR TREATMENT OF ACUTE RESPIRATORY DISTRESS SYNDROME (ARDS) IN CORONA VIRUS DISEASE (COVID-19) | Pharmazz, Inc. (US) | 2024-03-20 | — | — | EP | disclosed |
| CN-117440812-A | Pharmaceutical compositions and methods for treating Acute Respiratory Distress Syndrome (ARDS) in coronavirus disease (covd-19) | 法尔麦兹公司 | 2024-01-23 | — | — | CN | disclosed |
| WO-2022240964-A1 | PHARMACEUTICAL COMPOSITION AND METHOD FOR TREATMENT OF ACUTE RESPIRATORY DISTRESS SYNDROME (ARDS) IN CORONA VIRUS DISEASE (COVID-19) | PHARMAZZ, INC. (US) | 2022-11-17 | — | — | WO | disclosed |