Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 13/20 | 0.32 |
| ▸ | RXRG | P48443 | 9/20 | 0.32 |
| ▸ | RXRB | P28702 | 6/20 | 0.32 |
| ▸ | RARB | P10826 | 4/20 | 0.32 |
| ▸ | RARG | P13631 | 3/20 | 0.32 |
| ▸ | RARA | P10276 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 2/20 | 0.30 |
| ▸ | INMT | O95050 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | CASP1 | P29466 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | CASP7 | P55210 | 1/20 | 0.30 |
| ▸ | SMAD3 | P84022 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8309443 | 0.85 | RXRA (0.47) | RXRARXRGRXRBRARBRARG | |
| SCHEMBL8309439 | 0.85 | RXRA (0.47) | RXRARXRGRXRBRARBRARG | |
| SCHEMBL8323695 | 0.82 | RXRA (0.35) | RXRARXRGRXRBRARBRARG | |
| SCHEMBL8323032 | 0.81 | RXRA (0.36) | RXRARXRGRXRBRARBRARG | |
| SCHEMBL8524314 | 0.74 | RXRA (0.32) | RXRARXRGRXRBRARBRARG | |
| SCHEMBL8320884 | 0.72 | RXRA (0.32) | RXRARXRGRXRBRARBRARG | |
| SCHEMBL8015602 | 0.65 | RXRA (0.69) | RXRARXRGRXRBRARBRARG | |
| SCHEMBL6037058 | 0.65 | RXRA (0.52) | RXRARXRGRXRBRARBRARG | |
| SCHEMBL8313529 | 0.63 | RXRA (0.33) | RXRA | |
| SCHEMBL8417708 | 0.63 | RXRA (0.52) | RXRARXRGRXRBRARBRARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0800504-B1 | TRICYCLIC RETINOIDS, METHODS FOR THEIR PRODUCTION AND USE | LIGAND PHARM INC (US) | 1999-12-01 | — | — | EP | disclosed |