Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | CASP3 | P42574 | 1/20 | 0.42 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.42 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.42 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | TYR | P14679 | 1/20 | 0.42 |
| ▸ | CA7 | P43166 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 7/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.42 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8324956 | 0.89 | HDAC1 (0.54) | HDAC1HDAC6HDAC8HDAC2HDAC11 | |
| SCHEMBL8319464 | 0.89 | SMN1; SMN2 (0.46) | BRD4CASP3SENP8SENP7SENP6 | |
| SCHEMBL8322937 | 0.79 | CYP3A4 (0.49) | KDM4EKMT2ASMN1; SMN2CA12CA1 | |
| SCHEMBL3439436 | 0.79 | MEN1 (0.59) | CASP3SENP8SENP7SENP6KMT2A | |
| SCHEMBL8324031 | 0.79 | BRD4 (0.47) | BRD4KDM4EKMT2ASMN1; SMN2CA12 | |
| SCHEMBL8322975 | 0.77 | TGFBR1 (0.41) | HDAC1HDAC6HDAC8HDAC2HDAC11 | |
| SCHEMBL1305978 | 0.74 | PDE10A (0.51) | BRD4KMT2ASMN1; SMN2MAPTNPC1 | |
| SCHEMBL4833218 | 0.72 | CA12 (0.66) | KDM4EKMT2ASMN1; SMN2CA12CA1 | |
| SCHEMBL4833224 | 0.72 | CA12 (0.66) | KDM4EKMT2ASMN1; SMN2CA12CA1 | |
| SCHEMBL8325630 | 0.72 | CYP11B1 (0.48) | KDM4EKMT2ASMN1; SMN2CA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004063169-A1 | HYDROXAMID ACID DERIVATIVES AS HISTONE DEACETYLASE (HDAC) INHIBITORS | ASTELLAS PHARMA INC. (JP) | 2004-07-29 | — | — | WO | disclosed |