Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.59 |
| ▸ | RAB9A | P51151 | 2/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.59 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.55 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.55 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.55 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.55 |
| ▸ | HTR1A | P08908 | 1/20 | 0.55 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.55 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.55 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.55 |
| ▸ | RXRA | P19793 | 2/20 | 0.54 |
| ▸ | ATM | Q13315 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | CASP3 | P42574 | 1/20 | 0.51 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8318954 | 0.96 | LMNA (0.63) | MAPTRAB9ALMNAL3MBTL1PTGER1 | |
| SCHEMBL8325686 | 0.90 | LMNA (0.58) | MAPTRAB9ALMNAL3MBTL1PTGER1 | |
| SCHEMBL8322717 | 0.84 | PTGER1 (0.77) | MAPTRAB9ALMNAL3MBTL1PTGER1 | |
| SCHEMBL9064881 | 0.84 | PTGER1 (0.76) | MAPTPTGER1PTGER4PTGER3PTGER2 | |
| SCHEMBL9064386 | 0.82 | PTGER1 (0.73) | MAPTRAB9ALMNAL3MBTL1PTGER1 | |
| SCHEMBL8678180 | 0.82 | HTR1A (0.56) | MAPTRAB9ALMNAL3MBTL1HTR1A | |
| SCHEMBL8327569 | 0.82 | PTGER1 (0.73) | MAPTRAB9ALMNAL3MBTL1PTGER1 | |
| SCHEMBL8322752 | 0.82 | CYP4A11 (0.55) | MAPTRAB9ALMNAL3MBTL1ALDH1A1 | |
| SCHEMBL8320496 | 0.81 | KMT2A (0.57) | MAPTRAB9ALMNAL3MBTL1PTGER1 | |
| SCHEMBL8406671 | 0.79 | HTR1A (0.66) | MAPTRAB9ALMNAL3MBTL1PTGER1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0733033-B1 | PHARMACEUTICALLY ACTIVE SUBSTITUTED AROMATIC COMPOUNDS | ZENECA LTD (GB) | 1999-12-22 | — | — | EP | disclosed |
| US-5811459-A | PAIN RELIEVERS | ZENECA LIMITED (GB) | 1998-09-22 | — | — | US | disclosed |
| EP-0733033-A1 | PHARMACEUTICALLY ACTIVE SUBSTITUTED AROMATIC COMPOUNDS | ZENECA LIMITED (GB) | 1996-09-25 | — | — | EP | disclosed |