Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.50 |
| ▸ | HTR1A | P08908 | 2/20 | 0.44 |
| ▸ | HTR2A | P28223 | 2/20 | 0.44 |
| ▸ | HTR7 | P34969 | 2/20 | 0.44 |
| ▸ | DRD3 | P35462 | 2/20 | 0.44 |
| ▸ | HTR2B | P41595 | 2/20 | 0.44 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.36 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.36 |
| ▸ | PREP | P48147 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 2/20 | 0.35 |
| ▸ | DRD4 | P21917 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | HRH1 | P35367 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1539683 | 0.96 | ACHE (0.53) | ACHEHTR1AHTR2AHTR7DRD3 | |
| SCHEMBL27440472 | 0.94 | ACHE (0.51) | ACHEHTR1AHTR2AHTR7DRD3 | |
| SCHEMBL27387272 | 0.89 | ACHE (0.47) | ACHEHTR1AHTR2AHTR7DRD3 | |
| Hydrochloric Acid SCHEMBL6764862 | 0.83 | ACHE (0.49) | ACHEHTR1AHTR2AHTR7DRD3 | |
| Hydrochloric Acid SCHEMBL7208000 | 0.81 | ACHE (0.40) | ACHEHTR1AHTR2AHTR7DRD3 | |
| SCHEMBL1539753 | 0.80 | HTR1A (0.51) | ACHEHTR1AHTR2AHTR7DRD3 | |
| SCHEMBL4088847 | 0.79 | ACHE (0.49) | ACHEHTR1AHTR2AHTR7DRD3 | |
| SCHEMBL1451967 | 0.79 | ACHE (0.51) | ACHEHTR1AHTR2AHTR7DRD3 | |
| SCHEMBL577446 | 0.79 | HTR1A (0.57) | ACHEHTR1AHTR2AHTR7DRD3 | |
| SCHEMBL11503247 | 0.78 | HTR1A (0.49) | ACHEHTR1AHTR2AHTR7DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1113890-C | Heterocyclic metallocenes and polymerization catalysts | MONTELL TECHNOLOGY COMPANY BV (NL) | 2003-07-09 | — | — | CN | disclosed |
| CN-1068332-C | Metalocenes compound | HOECHST AG (DE) | 2001-07-11 | — | — | CN | disclosed |
| CN-1244201-A | Heterocyclic metallocenes and polymerization catalysts | MONTELL TECHNOLOGY COMPANY BV (NL) | 2000-02-09 | — | — | CN | disclosed |
| EP-0938491-A1 | HETEROCYCLIC METALLOCENES AND POLYMERIZATION CATALYSTS | Montell Technology Company B.V. (NL) | 1999-09-01 | — | — | EP | disclosed |
| WO-1998022486-A1 | HETEROCYCLIC METALLOCENES AND POLYMERIZATION CATALYSTS | MONTELL TECHNOLOGY COMPANY B.V. (NL) | 1998-05-28 | — | — | WO | disclosed |
| CN-1107854-A | Metalocenes compound | HOECHST AG (DE) | 1995-09-06 | — | — | CN | disclosed |