Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | YAP1 | P46937 | 1/20 | 0.39 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.39 |
| ▸ | TEAD2 | Q15562 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | PDE6D | O43924 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.38 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.38 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.37 |
| ▸ | LPAR1 | Q92633 | 2/20 | 0.37 |
| ▸ | LPAR5 | Q9H1C0 | 2/20 | 0.37 |
| ▸ | NSD2 | O96028 | 1/20 | 0.36 |
| ▸ | TSPO | P30536 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | APEX1 | P27695 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8326314 | 0.87 | TDP1 (0.42) | TDP1YAP1TEAD4TEAD2ALDH1A1 | |
| SCHEMBL8330600 | 0.85 | KDM1A (0.39) | YAP1TEAD4TEAD2ROCK1RIPK1 | |
| SCHEMBL8328152 | 0.80 | RIPK1 (0.38) | TDP1YAP1TEAD4TEAD2ALDH1A1 | |
| SCHEMBL7609127 | 0.75 | ALDH1A1 (0.50) | TDP1YAP1TEAD4TEAD2ALDH1A1 | |
| SCHEMBL8329333 | 0.73 | KDM1A (0.40) | TDP1YAP1TEAD4TEAD2RIPK1 | |
| SCHEMBL8330238 | 0.72 | TDP1 (0.42) | TDP1ALDH1A1LMNATAS2R14RIPK1 | |
| SCHEMBL8331046 | 0.70 | CA12 (0.50) | TDP1ROCK1POLBAPEX1 | |
| SCHEMBL8327663 | 0.69 | ROCK1 (0.44) | TDP1YAP1TEAD4TEAD2ALDH1A1 | |
| SCHEMBL19545290 | 0.69 | HDAC3 (0.40) | YAP1TEAD4TEAD2ROCK1RIPK1 | |
| SCHEMBL8328009 | 0.69 | ADRB2 (0.44) | TDP1YAP1TEAD4TEAD2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0760368-B1 | PYRIMIDINE DERIVATIVES | NISSHIN FLOUR MILLING CO (JP) | 1999-07-28 | — | — | EP | disclosed |
| US-5736550-A | TREATMENT OF GASTROINTESTINAL TRACT DISORDERS | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1998-04-07 | — | — | US | disclosed |
| EP-0760368-A1 | NOVEL PYRIMIDINE DERIVATIVE | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1997-03-05 | — | — | EP | disclosed |