SCHEMBL8324728

SCHEMBL8324728

Clc1ccccc1CN1CNc2ccccc2C1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 6/20 0.48
SIGMAR1 Q99720 2/20 0.48
DRD3 P35462 2/20 0.48
KCNH2 Q12809 2/20 0.48
OPRM1 P35372 2/20 0.48
OPRK1 P41145 2/20 0.48
USP2 O75604 1/20 0.48
ABCB11 O95342 1/20 0.48
LMNA P02545 1/20 0.48
CYP1A2 P05177 1/20 0.48
CYP3A4 P08684 1/20 0.48
ADRA2A P08913 1/20 0.48
ADORA3 P0DMS8 1/20 0.48
CYP2D6 P10635 1/20 0.48
CYP2C9 P11712 1/20 0.48
ADRB3 P13945 1/20 0.48
ADRA2B P18089 1/20 0.48
ADRA2C P18825 1/20 0.48
CYP2B6 P20813 1/20 0.48
DRD1 P21728 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8329606 0.81 ALDH1A1 (0.54) ALDH1A1SIGMAR1DRD3KCNH2CYP1A2
SCHEMBL8323088 0.80 DRD3 (0.46) ALDH1A1SIGMAR1DRD3KCNH2OPRM1
SCHEMBL14149407 0.74 BRD4 (0.41) ALDH1A1CYP1A2CYP2D6CYP2C19MAPK1
SCHEMBL10754509 0.73 ALDH1A1 (0.67) ALDH1A1SIGMAR1DRD3KCNH2OPRM1
Hydrochloric Acid SCHEMBL11381615 0.72 KDM4E (0.68) ALDH1A1SIGMAR1DRD3KCNH2OPRM1
SCHEMBL11360607 0.70 SIGMAR1 (0.85) ALDH1A1SIGMAR1KCNH2LMNAKDM4E
SCHEMBL23420113 0.70 BRD4 (0.38) ALDH1A1CYP1A2CYP2D6CYP2C19MAPK1
SCHEMBL30758051 0.69 OPRM1 (0.45) ALDH1A1DRD3KCNH2OPRM1OPRK1
SCHEMBL9417737 0.68 SIGMAR1 (0.72) ALDH1A1SIGMAR1KDM4EATMSMN1; SMN2
SCHEMBL23851311 0.68 SIGMAR1 (0.72) ALDH1A1SIGMAR1KDM4EATMSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0912180-A1 HETEROCYCLIC COMPOUNDS WITH THROMBOLYTIC ACTIVITY AND THEIR USE FOR TREATING THROMBOSIS Dupin, Jean-Pierre (FR) 1999-05-06 EP claimed
WO-1998002162-A1 HETEROCYCLIC COMPOUNDS WITH THROMBOLYTIC ACTIVITY AND THEIR USE FOR TREATING THROMBOSIS DUPIN JEAN PIERRE (FR) 1998-01-22 WO claimed
EP-0912180-A1 HETEROCYCLIC COMPOUNDS WITH THROMBOLYTIC ACTIVITY AND THEIR USE FOR TREATING THROMBOSIS Dupin, Jean-Pierre (FR) 1999-05-06 EP disclosed
WO-1998002162-A1 HETEROCYCLIC COMPOUNDS WITH THROMBOLYTIC ACTIVITY AND THEIR USE FOR TREATING THROMBOSIS DUPIN JEAN PIERRE (FR) 1998-01-22 WO disclosed