Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.47 |
| ▸ | ACHE | P22303 | 3/20 | 0.47 |
| ▸ | MC4R | P32245 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31332341 | 0.83 | SIGMAR1 (0.54) | ALDH1A1TDP1SIGMAR1ACHEMC4R | |
| SCHEMBL8324728 | 0.81 | ALDH1A1 (0.48) | ALDH1A1SIGMAR1CYP1A2MEN1KMT2A | |
| SCHEMBL30758051 | 0.79 | OPRM1 (0.45) | ALDH1A1TDP1ACHEMEN1KMT2A | |
| SCHEMBL14149407 | 0.79 | BRD4 (0.41) | ALDH1A1CYP1A2THRBMAPK1 | |
| SCHEMBL6372488 | 0.78 | ACHE (0.53) | ACHEDRD3 | |
| SCHEMBL8468572 | 0.78 | ALDH1A1 (0.49) | ALDH1A1TDP1SIGMAR1MC4RCYP1A2 | |
| SCHEMBL6672942 | 0.77 | SIGMAR1 (0.62) | SIGMAR1ACHEMC4RCYP1A2DRD3 | |
| SCHEMBL31332406 | 0.76 | EPHX2 (0.57) | ALDH1A1SIGMAR1ACHEMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL16713355 | 0.75 | SIGMAR1 (0.60) | SIGMAR1ACHEMC4RCYP1A2DRD3 | |
| SCHEMBL4447555 | 0.75 | ALDH1A1 (0.58) | ALDH1A1TDP1SIGMAR1ACHETHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1228701-A | Heterocyclic compounds with thrombolytic activity and their use for treating thrombosis | DUPIN JEAN PIERRE (FR) | 1999-09-15 | — | — | CN | claimed |
| EP-0912180-A1 | HETEROCYCLIC COMPOUNDS WITH THROMBOLYTIC ACTIVITY AND THEIR USE FOR TREATING THROMBOSIS | Dupin, Jean-Pierre (FR) | 1999-05-06 | — | — | EP | claimed |
| WO-1998002162-A1 | HETEROCYCLIC COMPOUNDS WITH THROMBOLYTIC ACTIVITY AND THEIR USE FOR TREATING THROMBOSIS | DUPIN JEAN PIERRE (FR) | 1998-01-22 | — | — | WO | claimed |
| CN-1228701-A | Heterocyclic compounds with thrombolytic activity and their use for treating thrombosis | DUPIN JEAN PIERRE (FR) | 1999-09-15 | — | — | CN | disclosed |
| EP-0912180-A1 | HETEROCYCLIC COMPOUNDS WITH THROMBOLYTIC ACTIVITY AND THEIR USE FOR TREATING THROMBOSIS | Dupin, Jean-Pierre (FR) | 1999-05-06 | — | — | EP | disclosed |
| WO-1998002162-A1 | HETEROCYCLIC COMPOUNDS WITH THROMBOLYTIC ACTIVITY AND THEIR USE FOR TREATING THROMBOSIS | DUPIN JEAN PIERRE (FR) | 1998-01-22 | — | — | WO | disclosed |