Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 3/20 | 0.51 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.51 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.50 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.50 |
| ▸ | CCR5 | P51681 | 2/20 | 0.49 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.48 |
| ▸ | USP28 | Q96RU2 | 1/20 | 0.48 |
| ▸ | USP25 | Q9UHP3 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | APP | P05067 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.47 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8324067 | 0.92 | ABCB1 (0.53) | ABCB1ABCG2MTNR1AMTNR1BCCR5 | |
| SCHEMBL8322935 | 0.90 | CCR5 (0.49) | CCR5LRRK2USP28USP25ALDH1A1 | |
| SCHEMBL8325289 | 0.88 | ABCB1 (0.62) | ABCB1ABCG2MTNR1AMTNR1BLMNA | |
| SCHEMBL8324940 | 0.85 | CCR5 (0.53) | ABCB1ABCG2CCR5USP28USP25 | |
| SCHEMBL8409537 | 0.85 | CCR5 (0.53) | ABCB1ABCG2CCR5USP28USP25 | |
| SCHEMBL8326037 | 0.82 | CCR5 (0.46) | MTNR1AMTNR1BCCR5LRRK2USP28 | |
| SCHEMBL14891403 | 0.82 | FFAR4 (0.54) | CCR5LRRK2ALDH1A1LMNAHDAC1 | |
| SCHEMBL8322308 | 0.82 | PTGER4 (0.59) | ABCB1ABCG2MTNR1AMTNR1BLMNA | |
| SCHEMBL8323808 | 0.81 | CCR5 (0.47) | MTNR1AMTNR1BCCR5LRRK2USP28 | |
| SCHEMBL8321056 | 0.81 | FOLH1 (0.51) | CCR5USP28USP25ALDH1A1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0733033-B1 | PHARMACEUTICALLY ACTIVE SUBSTITUTED AROMATIC COMPOUNDS | ZENECA LTD (GB) | 1999-12-22 | — | — | EP | disclosed |
| US-5811459-A | PAIN RELIEVERS | ZENECA LIMITED (GB) | 1998-09-22 | — | — | US | disclosed |
| EP-0733033-A1 | PHARMACEUTICALLY ACTIVE SUBSTITUTED AROMATIC COMPOUNDS | ZENECA LIMITED (GB) | 1996-09-25 | — | — | EP | disclosed |